Micheline Re
Institut Gustave Roussy
11 Papers
158 Citations
Micheline Re is an academic researcher from Institut Gustave Roussy. The author has contributed to research in topics: Chemistry & Pharmacokinetics. The author has an hindex of 10, co-authored 11 publications.
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Papers
Pharmacokinetic-pharmacodynamic relationships of imatinib and its main metabolite in patients with advanced gastrointestinal stromal tumors.
C. Delbaldo,Etienne Chatelut,Micheline Re,Alain Deroussent,Sophie Séronie-Vivien,Aurore Jambu,P. Berthaud,Axel Le Cesne,Jean-Yves Blay,Gilles Vassal +9 more
TL;DR: The plasma AAG levels influenced imatinib pharmacokinetics, with the plasma α1-acid glycoprotein (AAG) levels indicating that both clearance values decreased at a higher AAG level.
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Simultaneous determination of the camptothecin analogue CPT-11 and its active metabolite SN-38 by high-performance liquid chromatography: application to plasma pharmacokinetic studies in cancer patients
Iman Barilero,D. Gandia,Jean-Pierre Armand,Anne Mathieu-Boué,Micheline Re,Alain Gouyette,Guy G. Chabot +6 more
TL;DR: Using this assay, plasma pharmacokinetics of both I and II were simultaneously determined in three patients receiving 100 mg/m2 I as a 30-min intravenous infusion, and the method showed good precision.
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Metabolism of sanguinarine in human and in rat: characterization of oxidative metabolites produced by human CYP1A1 and CYP1A2 and rat liver microsomes using liquid chromatography-tandem mass spectrometry.
TL;DR: Investigating the oxidative metabolites of SA formed during incubations with rat liver microsomes (RLM) and recombinant human cytochrome P450 (CYP) and to tentatively identify the CYP isoforms involved in SA detoxification and to investigate the oxidative biotransformation of SA was investigated using eight human CYPs.
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Induction of glutathione synthesis explains pharmacodynamics of high-dose busulfan in mice and highlights putative mechanisms of drug interaction
Jérôme Bouligand,Alain Deroussent,Nicolas Simonnard,Paule Opolon,Jackie Morizet,Elisabeth Connault,Estelle Daudigeos,Micheline Re,Angelo Paci,Gilles Vassal +9 more
TL;DR: This is the first time that in vivo flux of GSH synthesis has been shown to be closely related to a drug plasma clearance and toxicity in mice, and allows hypothesizing that GSH liver synthesis may directly influence busulfan clearance in humans.
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