Michela Rigoni
University of Padua
45 Papers
248 Citations
Michela Rigoni is an academic researcher from University of Padua. The author has contributed to research in topics: Neuromuscular junction & Axon. The author has an hindex of 19, co-authored 36 publications. Previous affiliations of Michela Rigoni include National Research Council.
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Papers
Snake presynaptic neurotoxins with phospholipase A2 activity induce punctate swellings of neurites and exocytosis of synaptic vesicles
Michela Rigoni,Giampietro Schiavo,Anne Weston,Paola Caccin,Federica Allegrini,Maria Pennuto,Flavia Valtorta,Cesare Montecucco,Ornella Rossetto +8 more
TL;DR: Findings indicate that these snake presynaptic neurotoxins act with by same mechanism and that the observed phenotype results from the fusion of synaptic vesicles with the plasma membrane not balanced by an adequate membrane retrieval.
CXCL12α/SDF-1 from perisynaptic Schwann cells promotes regeneration of injured motor axon terminals.
Samuele Negro,Francesca Lessi,Elisa Duregotti,Paolo Aretini,Marco La Ferla,Sara Franceschi,Michele Menicagli,Elisanna Bergamin,Egle Radice,Marcus Thelen,Aram Megighian,Marco Pirazzini,Chiara Maria Mazzanti,Michela Rigoni,Cesare Montecucco +14 more
TL;DR: It is reported here that CXCL12α, also abbreviated as stromal‐derived factor‐1 (SDF‐1), is produced specifically by perisynaptic Schwann cells following motor axon terminal degeneration induced by α‐latrotoxin, and plays an important role in the regeneration of the neuromuscular junction after motor Axon injury.
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Site-directed mutagenesis identifies active-site residues of the light chain of botulinum neurotoxin type A.
TL;DR: Mutation of the Glu-262* nearly abolishes SNAP-25 hydrolysis as expected for a residue involved in zinc coordination and of a tyrosine and a phenylalanine residues that occupy critical positions within the active site of BoNT/A are presented.
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Mass spectrometry analysis of the phospholipase A2 activity of snake pre-synaptic neurotoxins in cultured neurons
Marco Paoli,Michela Rigoni,Grielof Koster,Ornella Rossetto,Cesare Montecucco,Anthony D. Postle +5 more
TL;DR: Results deriving from the first chemical analysis of the action of these neurotoxic phospholipases in neurons, made possible by the use of high sensitivity mass spectrometry, suggest that most PLA2 hydrolysis takes place on the cell surface.
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Signals Orchestrating Peripheral Nerve Repair.
Michela Rigoni,Samuele Negro +1 more
TL;DR: The main intrinsic and extrinsic mechanisms allowing severed peripheral axons to re-grow are reviewed, and some alarm mediators and pro-regenerative molecules and pathways involved in the process are discussed, highlighting the role of Schwann cells as central hubs coordinating multiple signals.
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