Michela Asperti
University of Brescia
29 Papers
34 Citations
Michela Asperti is an academic researcher from University of Brescia. The author has contributed to research in topics: Hepcidin & Chemistry. The author has an hindex of 11, co-authored 22 publications.
Chat about Author
Papers
NCOA4-mediated ferritinophagy promotes ferroptosis induced by erastin, but not by RSL3 in HeLa cells.
TL;DR: Interestingly, it was found that erastin promoted ferritinophagy in HeLa cells expressing NCOA4, increasing the free iron, lipid peroxidation and the sensitivity to ferroptosis.
117
Cell growth potential drives ferroptosis susceptibility in rhabdomyosarcoma and myoblast cell lines
Silvia Codenotti,Maura Poli,Michela Asperti,Daniela Zizioli,Francesco Marampon,Alessandro Fanzani +5 more
TL;DR: The combination of erastin or RSL3 with chemotherapeutic doxorubicin and actinomycin D agents to be effective in increasing cell death in all RMS lines.
68
Mice lacking mitochondrial ferritin are more sensitive to doxorubicin-mediated cardiotoxicity.
Federica Maccarinelli,Elena Gammella,Michela Asperti,Maria Regoni,Giorgio Biasiotto,Emilia Turco,Fiorella Altruda,Silvia Lonardi,Laura Cornaghi,Elena Donetti,Stefania Recalcati,Maura Poli,Dario Finazzi,Paolo Arosio,Gaetano Cairo +14 more
TL;DR: The results show that the absence of FtMt, which is highly expressed in the heart, increases the sensitivity of heart mitochondria to the toxicity of doxorubicin, which represents the first in vivo evidence of the antioxidant role of Ftmt.
Oversulfated heparins with low anticoagulant activity are strong and fast inhibitors of hepcidin expression in vitro and in vivo.
Maura Poli,Michela Asperti,Paola Ruzzenenti,Luca Mandelli,Natascia Campostrini,Giuliana Martini,Margherita Di Somma,Federica Maccarinelli,Domenico Girelli,Annamaria Naggi,Paolo Arosio +10 more
TL;DR: A modified heparin type is analyzed, characterized by a high, almost saturated, sulfation degree and low molecular weight, that inhibited hepcidin expression in hepatic HepG2 cells, and when used in mice, it readily suppressed liver hePCidin mRNA and serum hepcIDin, with a significant decrease of spleen iron.
41
Non-Anticoagulant Heparins Are Hepcidin Antagonists for the Treatment of Anemia
TL;DR: Recent findings on the anti-hepcidin activity of heparins and their possible use for the treatment of anemia caused by hepcidIn excess, including the anemia of chronic diseases are summarized.
24