Michel Pagès
University of Montpellier
42 Papers
516 Citations
Michel Pagès is an academic researcher from University of Montpellier. The author has contributed to research in topics: Genome & Chromosome. The author has an hindex of 21, co-authored 42 publications. Previous affiliations of Michel Pagès include Centre national de la recherche scientifique.
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Papers
FISH analysis reveals aneuploidy and continual generation of chromosomal mosaicism in Leishmania major
TL;DR: It is shown that the transmission of genetic material during mitosis is highly unstable in this ‘divergent’ eukaryote: this leads to continual generation of chromosomal mosaicism, and a model for the occurrence and persistence of this mosaicism is proposed.
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Novel insights into genome plasticity in Eukaryotes: mosaic aneuploidy in Leishmania
TL;DR: First, mosaic aneuploidy might be considered as a powerful strategy evolved by the parasite for adapting to modifications of environment conditions as well as for the emergence of drug resistance.
133
Conserved linkage groups associated with large-scale chromosomal rearrangements between Old World and New World Leishmania genomes.
Constança Britto,Christophe Ravel,Patrick Bastien,Christine Blaineau,Michel Pagès,J. P. Dedet,Patrick Wincker +6 more
TL;DR: Results show that large-scale chromosomal rearrangements occurred during the evolution of the genus Leishmania, and that the three main groups of pathogenic species are characterized by different chromosome numbers.
120
Haplotype selection as an adaptive mechanism in the protozoan pathogen Leishmania donovani
Pablo Prieto Barja,Pascale Pescher,Giovanni Bussotti,Franck Dumetz,Hideo Imamura,Darek Kedra,Malgorzata A. Domagalska,Victor Chaumeau,Heinz Himmelbauer,Michel Pagès,Yvon Sterkers,Jean-Claude Dujardin,Jean-Claude Dujardin,Cedric Notredame,Gerald F. Späth +14 more
TL;DR: It is shown that aneuploidy turnover and haplotype selection are two mechanisms by which L. donovani adapts to environmental fluctuations inside the mammalian host and that karyotypic fluctuations allow for selection of beneficial haplotypes.