Michaela Blanfeld
University of Mainz
6 Papers
Michaela Blanfeld is an academic researcher from University of Mainz. The author has contributed to research in topics: Experimental autoimmune encephalomyelitis & Gene. The author has an hindex of 3, co-authored 4 publications.
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Papers
IL-17 controls central nervous system autoimmunity through the intestinal microbiome
Tommy Regen,Sandrine Isaac,Ana Amorim,Nicolás Gonzalo Núñez,Judith Hauptmann,Arthi Shanmugavadivu,Matthias Klein,Roman Sankowski,Ilgiz A. Mufazalov,Nir Yogev,Jula Huppert,Florian Wanke,Michael Witting,Alexandra Grill,Eric J. C. Gálvez,Alexei Nikolaev,Michaela Blanfeld,Immo Prinz,Philippe Schmitt-Kopplin,Till Strowig,Christoph Reinhardt,Marco Prinz,Tobias Bopp,Burkhard Becher,Carles Ubeda,Ari Waisman +25 more
TL;DR: This paper showed that mice deficient for IL-17A/F lose their susceptibility to EAE, which correlated with an altered composition of their gut microbiota, which indirectly alter CNS-directed autoimmunity.
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Cutting Edge: IL-6-Driven Immune Dysregulation Is Strictly Dependent on IL-6R α-Chain Expression.
Ilgiz A. Mufazalov,Ilgiz A. Mufazalov,David Andruszewski,Carsten Schelmbauer,Sylvia Heink,Michaela Blanfeld,Joumana Masri,Yilang Tang,Rebecca Schüler,Christina Eich,F. Thomas Wunderlich,F. Thomas Wunderlich,Susanne Karbach,Jeffrey A. Bluestone,Thomas Korn,Ari Waisman +15 more
TL;DR: Constitutive IL-6 overproduction promotes myeloid cell–driven inflammation and it is clarified that IL- 6Rα is the only biologically relevant receptor forIL-6 in mice.
β2 Integrins on Dendritic Cells Modulate Cytokine Signaling and Inflammation-Associated Gene Expression, and Are Required for Induction of Autoimmune Encephalomyelitis
Monika Bednarczyk,V. Bolduan,Maximilian Haist,Henner Stege,Christoph Hieber,Lisa Johann,Carsten Schelmbauer,Michaela Blanfeld,Khalad Karram,J. Schunke,Tanja Klaus,Ingrid Tubbe,Evelyn Montermann,Nadine Röhrig,Maike Hartmann,Jana Schlosser,Tobias Bopp,Björn E. Clausen,Ari Waisman,Matthias Bros,Stephan Grabbe +20 more
TL;DR: A CD18 gene floxed mouse strain is generated and may prove to be a valuable tool to study the leukocyte-specific functions of β2 integrins in vivo.
B cells maintain the homeostasis of splenic marginal zone antigen-presenting cells to promote the anti-viral CD8+ T cell response
Xinyuan Liu,Filiz Demircik,Mariia Antipova,Stylianakis Emmanouil,Matthias Klein,D. Bejarano,Abdelrahman Elwy,Anna Ebering,Michaela Blanfeld,Katlynn Carter,Lisa Johann,David C. Uhlfelder,Elisa Blickberndt,Hans Christian Probst,Nadine Hövelmeyer,Tobias Bopp,Ramon Arens,Joke M. M. den Haan,Jennifer L. Gommerman,Esther von Stebut,B. E. Clausen,Andreas Schlitzer,Karl S Lang,Ronald A Backer,Niels A. W. Lemmermann,A. Waisman +25 more
Targeting transcription factor Stat4 uncovers a role for interleukin-18 in the pathogenesis of severe lupus nephritis in mice
Julia Menke,Tillmann Bork,Birte Kutska,Katelyn T. Byrne,Michaela Blanfeld,Manfred Relle,Vicki Rubin Kelley,Andreas Schwarting +7 more
TL;DR: The Stat4 and IL-12 (an activator of Stat4)-independent factor, IL-18, can drive autoimmune lupus nephritis in MRL-Fas(lpr) mice.