Michael Walden
Hannover Medical School
13 Papers
183 Citations
Michael Walden is an academic researcher from Hannover Medical School. The author has contributed to research in topics: LEKTI & Mass spectrometry. The author has an hindex of 10, co-authored 13 publications.
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Papers
Analytical procedures for quantification of peptides in pharmaceutical research by liquid chromatography–mass spectrometry
TL;DR: Procedures based on LC–MS techniques for quantitative determination of peptides are reviewed using numerous examples from the literature, complemented by experiments and results from the laboratory.
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LEKTI: a multidomain serine proteinase inhibitor with pathophysiological relevance.
Hans-Jürgen Mägert,Peter Kreutzmann,Ludger Ständker,Michael Walden,Katrin Drogemuller,Wolf-Georg Forssmann +5 more
TL;DR: An overview of the already known data on the structure, processing, gene expression, and pathophysiological role of LEKTI is given.
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•Journal Article
The 15-domain serine proteinase inhibitor LEKTI: biochemical properties, genomic organization, and pathophysiological role.
Hans-Jürgen Mägert,Peter Kreutzmann,Katrin Drogemuller,Ludger Ständker,Knut Adermann,Michael Walden,Harald John,H C Korting,Wolf-Georg Forssmann +8 more
TL;DR: This work succeeded in partially isolating and cloning a novel human serine proteinase inhibitor which, according to its structure and the expression pattern of the corresponding gene, was termed lympho-epithelial Kazal-type-related inhibitor (LEKTI).
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Purification and characterization of the first archaeal aconitase from the thermoacidophilic Sulfolobus acidocaldarius
TL;DR: The first archaeal aconitase was isolated from the cytosol of the thermoacidophilic Sulfolobus acidocaldarius, Interestingly, the enzyme was copurified with an isocitrate lyase, which was unknown in crenarchaeota, thus far.
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Biochemical features, molecular biology and clinical relevance of the human 15-domain serine proteinase inhibitor LEKTI.
Michael Walden,Peter Kreutzmann,Katrin Drogemuller,Harald John,Wolf-Georg Forssmann,Hans-Jürgen Mägert +5 more
TL;DR: Based on the isolation of a 55 amino acid peptide from human hemofiltrate, the cDNA for a novel human 15-domain serine proteinase inhibitor termed LEKTI was cloned and a trypsininhibiting activity was demonstrated for three different domains.
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