Michael T. Boyne
Center for Drug Evaluation and Research
49 Papers
500 Citations
Michael T. Boyne is an academic researcher from Center for Drug Evaluation and Research. The author has contributed to research in topics: Mass spectrometry & Chemistry. The author has an hindex of 23, co-authored 45 publications. Previous affiliations of Michael T. Boyne include University of Illinois at Urbana–Champaign & Food and Drug Administration.
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Papers
Targeted Peptide Measurements in Biology and Medicine: Best Practices for Mass Spectrometry-based Assay Development Using a Fit-for-Purpose Approach
Steven A. Carr,Susan E. Abbatiello,Bradley L. Ackermann,Christoph H. Borchers,Bruno Domon,Eric W. Deutsch,Russell P. Grant,Andrew N. Hoofnagle,Ruth Hüttenhain,Ruth Hüttenhain,John M. Koomen,Daniel C. Liebler,Tao Liu,Brendan MacLean,D. R. Mani,Elizabeth Mansfield,Hendrik Neubert,Amanda G. Paulovich,Lukas Reiter,Olga Vitek,Ruedi Aebersold,Leigh Anderson,Robert Bethem,Josip Blonder,Emily S. Boja,Julianne Cook Botelho,Michael T. Boyne,Ralph A. Bradshaw,Alma L. Burlingame,Daniel W. Chan,Hasmik Keshishian,Eric Kuhn,Christopher R. Kinsinger,Jerry S.H. Lee,Jerry S.H. Lee,Sang Won Lee,Robert L. Moritz,Juan A. Oses-Prieto,Nader Rifai,James C. Ritchie,Henry Rodriguez,Pothur R. Srinivas,Raymond R. Townsend,Jennifer E. Van Eyk,Gordon Whiteley,Arun P. Wiita,Susan T. Weintraub +46 more
TL;DR: A workshop was held at the National Institutes of Health with representatives from the multiple communities developing and employing targeted MS assays and defined three tiers of assays distinguished by their performance and extent of analytical characterization.
608
Precise characterization of human histones in the H2A gene family by top down mass spectrometry.
TL;DR: This unequivocal identification of H2A forms illustrates the advantages of Top Down Mass Spectrometry and provides a global perspective of H 2A regulation through the cell cycle.
163
Biosynthesis of pipecolic acid by RapL, a lysine cyclodeaminase encoded in the rapamycin gene cluster
TL;DR: This work represents the first in vitro characterization of a lysine cyclodeaminase, a member of a unique group of enzymes which utilize the nicotinamide cofactor in a catalytic manner and accepts L-ornithine as a substrate, albeit with a significantly reduced catalytic efficiency.
150
Hydroxymalonyl-acyl carrier protein (ACP) and aminomalonyl-ACP are two additional type I polyketide synthase extender units
Yolande A. Chan,Michael T. Boyne,Angela M. Podevels,Amy K. Klimowicz,Jo Handelsman,Neil L. Kelleher,Michael G. Thomas +6 more
TL;DR: Evidence shows the formation of ACP-linked extender units for polyketide synthesis of zwittermicin A, and Interestingly, aminomalonyl-ACP formation involves enzymology typically found in nonribosomal peptide synthesis.
133
Top-Down Proteomics on a Chromatographic Time Scale Using Linear Ion Trap Fourier Transform Hybrid Mass Spectrometers
Bryan A. Parks,Lihua Jiang,Paul M. Thomas,Craig D. Wenger,Michael J. Roth,Michael T. Boyne,Patricia V. Burke,Kurt E. Kwast,Neil L. Kelleher +8 more
TL;DR: This is the first demonstration of top-down proteomics (i.e., many identifications) on linear ion trap Fourier transform (LTQ FT) systems using high-resolution MS/MS data obtained on a chromatographic time scale.
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