Michael Sheinman
Utrecht University
47 Papers
86 Citations
Michael Sheinman is an academic researcher from Utrecht University. The author has contributed to research in topics: Ductal carcinoma & Breast cancer. The author has an hindex of 18, co-authored 40 publications. Previous affiliations of Michael Sheinman include Technion – Israel Institute of Technology & Netherlands Cancer Institute.
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Papers
Stress controls the mechanics of collagen networks
Albert James Licup,Stefan Münster,Stefan Münster,Abhinav Sharma,Michael Sheinman,Louise Jawerth,Ben Fabry,David A. Weitz,Fred C. MacKintosh +8 more
TL;DR: It is shown that the nonlinear stiffening of reconstituted type I collagen networks is controlled by the applied stress and that the network stiffness becomes surprisingly insensitive to network concentration, which suggests principles for the design of synthetic fiber networks with collagen-like properties, as well as a mechanism for the control of the mechanics of such networks.
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Strain-controlled criticality governs the nonlinear mechanics of fibre networks
Abhinav Sharma,Abhinav Sharma,Albert James Licup,Karin A. Jansen,Robbie Rens,Michael Sheinman,Gijsje H. Koenderink,Fred C. MacKintosh +7 more
TL;DR: In this paper, a combination of computational modelling of fiber networks and experiments on networks of type I collagen fibres was performed to study the nonlinear mechanics of collagen networks and quantitatively capture the predictions of scaling theory for the strain-controlled critical behaviour over a wide range of network concentrations and strains up to failure of the material.
Classes of fast and specific search mechanisms for proteins on DNA
TL;DR: This review focuses on the challenges posed by interactions between proteins, in particular transcription factors, and DNA and possible mechanisms which allow for fast and selective target location and introduces a new mechanism which is based on barrier discrimination.
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Searching Fast for a Target on DNA without Falling to Traps
TL;DR: A simple mechanism is suggested which can resolve this long-standing paradox between the speed and stability requirements of genomic expression and regulatory proteins.
110
Force percolation of contractile active gels.
José Alvarado,Michael Sheinman,Abhinav Sharma,Fred C. MacKintosh,Fred C. MacKintosh,Gijsje H. Koenderink +5 more
TL;DR: In this article, the authors present a state diagram that unifies a large body of experimental and theoretical studies on contractile active gels composed of actin filaments and myosin motors.
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