Michael Schirner
Free University of Berlin
93 Papers
826 Citations
Michael Schirner is an academic researcher from Free University of Berlin. The author has contributed to research in topics: Medicine & Metastasis. The author has an hindex of 29, co-authored 82 publications. Previous affiliations of Michael Schirner include Schering AG.
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Papers
Concurrent induction of lymphangiogenesis, angiogenesis, and macrophage recruitment by vascular endothelial growth factor-C in melanoma.
Mihaela Skobe,Leena Hamberg,Thomas Hawighorst,Michael Schirner,Gerald L. Wolf,Kari Alitalo,Michael Detmar +6 more
TL;DR: The presence of intratumoral lymphatics and enlargement of lymphatic vessels at the tumor periphery in vascular endothelial growth factor (VEGF)-C-overexpressing human melanomas transplanted onto nude mice is demonstrated and VEGF-C is identified as multifunctional factor involved in regulating tumor lymphangiogenesis, angiogenic, and immune response.
Design of therapeutic biomaterials to control inflammation
Zhaoxu Tu,Yiling Zhong,Han-bin Hu,Dan Shao,Rainer Haag,Michael Schirner,Jaewoo Lee,Bruce A. Sullenger,Kam W. Leong +8 more
TL;DR: In this article , the design of biomaterials for different anti-inflammatory therapeutic strategies is discussed, such as scavenging danger signals such as reactive oxygen and nitrogen species and cell-free DNA, in the early stages of inflammation.
Dendritic polyglycerol sulfates as multivalent inhibitors of inflammation
Jens Dernedde,Alexandra Rausch,Marie Weinhart,Sven Enders,Rudolf Tauber,Kai Licha,Michael Schirner,Ulrich Zügel,Arne von Bonin,Rainer Haag +9 more
TL;DR: Synthetic dendritic polyglycerol sulfates (dPGS) are investigated as macromolecular inhibitors that operate via a multivalent binding mechanism mimicking naturally occurring ligands that may be used for the treatment of inflammatory diseases.
273
Inflammation assessment in patients with arthritis using a novel in vivo fluorescence optical imaging technology
S. G. Werner,H.-E. Langer,Sarah Ohrndorf,Malte L. Bahner,Peter Schott,Carsten Schwenke,Michael Schirner,Hans Bastian,G. Lind-Albrecht,Bernward Kurtz,Gerd R Burmester,Marina Backhaus +11 more
TL;DR: Indocyanine green-enhanced FOI was more sensitive than CE and had good agreement with CE, US in power Doppler mode and MRI, while showing more positive results than these.
141
A novel function for the tumor suppressor p16(INK4a): induction of anoikis via upregulation of the alpha(5)beta(1) fibronectin receptor.
Thomas Plath,Katharina Detjen,M. Welzel,Zofia von Marschall,Derek Murphy,Michael Schirner,Bertram Wiedenmann,Stefan Rosewicz +7 more
TL;DR: Evidence that stable transfection of p16INK4a restitutes apoptosis induction upon loss of anchorage (anoikis) in a variety of human cancer cells is provided, suggesting a novel functional interference between a cell cycle–regulating tumor suppressor gene and membrane-bound integrins, thus regulating a hallmark feature of an epithelial transformed phenotype: susceptibility to anoikis.