The present invention relates to a method and a detection kit for diabetes susceptible risk prediction or diabetes treatment effect evaluation. According to the method for risk prediction and treatment evaluation of diabetes, the concentration of a biomarker in an individual diagnosis marker composition is mainly detected, the biomarker is mainly the amino acid, the fatty acid, the triglyceride or the glycohyodeoxycholic acid, and the like in blood plasma or blood serum, the related threshold is calculated according to the concentration, and comparative analysis is performed. With the method and the kit of the present invention, the experimental steps can be simplified, the detection efficiency can be improved, and the method and the kit are suitable for the early-stage risk prediction and the treatment effect evaluation of diabetes, and provide guidance for the individual medication treatment.

Method and kit for risk prediction and treatment evaluation of diabetes

The invention discloses a Guangxi rubus suavissimus antidiabetic potential marker metabolic pathway based on the metabonomics and a research method, which relates to a research method for a natural plant medicine action mechanism. The invention aims at solving the problems that the existing single pharmacology method cannot systematically and comprehensively evaluate the action mechanism of the natural plant medicine. The method comprises the following steps: (1) detecting and analyzing a urine metabolite of a diabetic rat after being induced by streptozotocin and intervened by rubus suavissimus; (2) selecting nine rubus suavissimus antidiabetic related urine potential markers, and identifying the potential markers; and (3) selecting six metabolic pathways of the rubus suavissimus for resisting the diabetics, and analyzing. By adopting the Guangxi rubus suavissimus antidiabetic potential marker metabolic pathway and the research method, the antidiabetic action mechanism of the rubus suavissimus can be more comprehensively, efficiently, rapidly and integrally evaluated without deviation, and evidence can be provided for the description and further development of the national medicine action mechanism.

Guangxi rubus suavissimus antidiabetic potential marker metabolic pathway based on metabonomics and research method

The invention provides use of acylcarnitine or detection reagent thereof. Specifically, through 6 years of follow-up study on 2103 residents, a targeted metabonomic strategy is employed to determine that an acylcarnitine spectrum, especially a long-chain acylcarnitine spectrum can be used as the marker for effective prediction of the onset risk of type 2 diabetes mellitus, and also can significantly improve the prediction ability of traditional risk factors for new-onset type 2 diabetes mellitus, thus providing favorable guidance for clinical diagnosis and treatment.

Application of acylcarnitine spectrum or detection reagent thereof in prediction of onset risk of type 2 diabetes mellitus

The present invention provides a method for assessing the presence or the risk of development of type 2 diabetes mellitus in a subject based on abundance data of several CAGs. Also provided is a method for evaluating efficacy of diet intervention or disease treatment in a subject having type 2 diabetes mellitus based on abundance data of these CAGs.

Biomarkers for type 2 diabetes mellitus and use thereof

PROBLEM TO BE SOLVED: To provide a method and an apparatus which measure an amount of cholesterol of apoE-containing HDL in serum with a small amount of a sample for a short time.SOLUTION: An apparatus for measuring an apoE-containing HDL includes: a sample feeder (10) which feeds serum being an object together with a buffer solution; a cation exchange column (20) which feeds the serum fed from the sample feeder; a heparin affinity column (30) which feeds a first effluent flowed out from the cation exchange column; a buffer solution feeder (80) which is provided between the cation exchange column and the heparin affinity column, and feeds an auxiliary buffer solution toward the heparin affinity column; a mixer (40) which mixes a reagent with a second effluent flowed out from the heparin affinity column to prepare a mixture liquid; and a detector (50) which irradiates the mixture liquid fed from the mixer with light having a predetermined wavelength to obtain a chromatogram; and adjusts ion concentration of the buffer solution to be fed to the cation exchange column (20) and the heparin affinity column (30).SELECTED DRAWING: Figure 1

Method and apparatus for measuring apoe-containing hdl

The present invention relates to a method of identifying a predisposition for developing type 2 diabetes mellitus in a subject, said method comprising the step of assessing in a sample obtained from said subject the amount of one or more metabolite(s) selected from (a) a first group comprising the metabolites glycine, lysoPhosphatidylcholine acyl C18:2, lysoPhosphatidylcholine acyl C17:0, lysoPhosphatidylcholine acyl C18:0, lysoPhosphatidylcholine acyl C18:1, phosphatidylcholine acyl-alkyl C34:2, phosphatidylcholine acyl-alkyl C36:2, phosphatidylcholine acyl-alkyl C36:3 and isobaric metabolites having the same molecular mass as glycine, lysoPhosphatidylcholine acyl C18:2, lysoPhosphatidylcholine acyl C17:0, lysoPhosphatidylcholine acyl C18:0, lysoPhosphatidylcholine acyl C18:1, phosphatidylcholine acyl-alkyl C34:2, phosphatidylcholine acyl-alkyl C36:2 or phosphatidylcholine acyl-alkyl C36:3 but different chemical formula; and/or (b) a second group comprising the metabolite acetylcarnitine C2 and an isobaric metabolite having the same molecular weight as acetylcarnitine C2 but different chemical formula; wherein a decrease in the amount of a metabolite selected from said first group or an increase in the amount of a metabolite selected from said second group as compared to the amount of the corresponding metabolite(s) of a control is indicative of a predisposition to develop type 2 diabetes mellitus. Further, the invention relates to a method of identifying a compound capable of preventing type 2 diabetes mellitus and diseases associated therewith or serving as a lead compound for developing a compound capable of preventing type 2 diabetes mellitus and diseases associated therewith and a method of selecting a therapy to prevent type 2 diabetes mellitus. Also, the invention relates to a kit.

Biomarkers for type 2 diabetes

Human Skeletal Muscle How Free Fatty Acids Inhibit Glucose Utilization in

Running title: Pfeiffer et al.; genome-wide DNA methylation and blood lipid levels

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Biomarkers for type 2 diabetes

Human Skeletal Muscle How Free Fatty Acids Inhibit Glucose Utilization in

Running title: Pfeiffer et al.; genome-wide DNA methylation and blood lipid levels