Michael Rajala
University of Michigan
13 Papers
6 Citations
Michael Rajala is an academic researcher from University of Michigan. The author has contributed to research in topics: Paneth cell & Stem cell. The author has an hindex of 7, co-authored 13 publications.
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Papers
Loss of Paneth Cell Autophagy Causes Acute Susceptibility to Toxoplasma gondii-Mediated Inflammation
Elise Burger,Alessandra Araujo,Américo H. López-Yglesias,Michael Rajala,Linda Geng,Beth Levine,Lora V. Hooper,Ezra Burstein,Felix Yarovinsky +8 more
TL;DR: It is demonstrated that the microbiota triggers basal Paneth cell-specific autophagy via induction of IFN-γ, a known trigger of autophagic, to maintain intestinal homeostasis and Atg5 expression in Paneth cells is essential for tissue protection against cytokine-mediated immunopathology during acute gastrointestinal infection.
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Leptin-inhibited PBN neurons enhance responses to hypoglycemia in negative energy balance
Jonathan N. Flak,Christa M. Patterson,Alastair S. Garfield,Giuseppe D'Agostino,Paulette B. Goforth,Amy K. Sutton,Paige A. Malec,Jenny Marie T. Wong,Mark Germani,Justin C. Jones,Michael Rajala,Leslie S. Satin,Christopher J. Rhodes,David P. Olson,Robert T. Kennedy,Lora K. Heisler,Martin G. Myers,Martin G. Myers +17 more
TL;DR: A previously unrecognized role for leptin and a population of leptin-regulated neurons that modulate the CRR to meet these challenges are identified in mice and may be a therapeutic target in hypoglycemia.
Cellular Plasticity of Defa4Cre-Expressing Paneth Cells in Response to Notch Activation and Intestinal Injury.
Jennifer C. Jones,Constance D. Brindley,Nicholas H. Elder,Martin G. Myers,Michael Rajala,Christopher M. Dekaney,Eóin N. McNamee,Mark R. Frey,Noah F. Shroyer,Peter J. Dempsey +9 more
TL;DR: The studies have shown that Defa4Cre-expressing Paneth cells possess cellular plasticity, can dedifferentiate into multipotent stem cells upon Notch activation, and can contribute to intestinal regeneration in an acute injury model.
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Leptin Acts Independently of Food Intake to Modulate Gut Microbial Composition in Male Mice
Michael Rajala,Christa M. Patterson,Judith S. Opp,Susan K. Foltin,Vincent B. Young,Martin G. Myers +5 more
TL;DR: Overall, the data reveal a role for LepRb signaling extrinsic to the intestinal epithelium and independent of food intake in the control of the gut microbiome.
Leptin action via LepR-b Tyr1077 contributes to the control of energy balance and female reproduction.
Christa M. Patterson,Eneida C. Villanueva,Megan Greenwald-Yarnell,Michael Rajala,Ian E. Gonzalez,Natinder Saini,Justin C. Jones,Martin G. Myers +7 more
TL;DR: The results suggest that signaling by LepR-b Tyr1077 plays a modest role in the control of metabolism by leptin, and is an important link between body adiposity and the reproductive axis.