Michael R. Hübner
Cold Spring Harbor Laboratory
5 Papers
Michael R. Hübner is an academic researcher from Cold Spring Harbor Laboratory. The author has contributed to research in topics: Histone code & Histone methyltransferase. The author has an hindex of 5, co-authored 5 publications.
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Papers
Multiple Structural Maintenance of Chromosome Complexes at Transcriptional Regulatory Elements
Jill M. Dowen,Steve Bilodeau,David A. Orlando,Michael R. Hübner,Brian J. Abraham,David L. Spector,Richard A. Young +6 more
TL;DR: In addition to their well-established functions in chromosome maintenance during mitosis, both cohesin and condensin II make important contributions to the functions of the key transcriptional regulatory elements during interphase.
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Nuclear organization and dynamics of 7SK RNA in regulating gene expression.
Kannanganattu V. Prasanth,Matthew Camiolo,Grace Chan,Vidisha Tripathi,Laurence Denis,Tetsuya Nakamura,Tetsuya Nakamura,Michael R. Hübner,David L. Spector +8 more
TL;DR: 7SK RNA transiently associates with the locus upon transcriptional down-regulation correlating with the displacement of pTEF-b, and results in the mislocalization of nuclear speckle constituents, and the transcriptional up-regulation of a reporter gene locus.
Role of H3K27 Demethylases Jmjd3 and UTX in Transcriptional Regulation
TL;DR: The role of the H3K27 demethylases Jmjd3 and UTX in gene expression is highlighted, which confers the plasticity necessary for changes in the gene-expression profile of a cell during differentiation or changes following environmental cues.
Chromatin organization and transcriptional regulation
Michael R. Hübner,Mélanie A. Eckersley-Maslin,Mélanie A. Eckersley-Maslin,David L. Spector,David L. Spector +4 more
TL;DR: This review focuses on recent findings that have contributed to the understanding of higher order chromatin structure and genome organization within the nucleus and highlights new findings on the dynamic positioning of genes relative to each other, as well as to their chromosome territory and the nuclear lamina.
Regulation of the Histone H4 Monomethylase PR-Set7 by CRL4Cdt2-Mediated PCNA-Dependent Degradation during DNA Damage
Hisanobu Oda,Michael R. Hübner,David B. Beck,Michiel Vermeulen,Jerard Hurwitz,David L. Spector,Danny Reinberg +6 more
TL;DR: It is found that PR-Set7 is indeed undetectable during S phase and instead is detected during late G2, mitosis, and early G1, demonstrating a stringent spatiotemporal control of PR- set7 that is essential for preserving the genomic integrity of mammalian cells.