Michael R. Blackburn
University of Texas Health Science Center at Houston
211 Papers
2.8K Citations
Michael R. Blackburn is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Adenosine & Adenosine deaminase. The author has an hindex of 63, co-authored 205 publications. Previous affiliations of Michael R. Blackburn include University of Texas at Austin & Thomas Jefferson University.
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Papers
Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent
Anren Song,Yujin Zhang,Leng Han,Gennady G. Yegutkin,Hong Liu,Kaiqi Sun,Angelo D'Alessandro,Jessica Li,Harry Karmouty-Quintana,Takayuki Iriyama,Takayuki Iriyama,Tingting Weng,Shushan Zhao,Shushan Zhao,Wei Wang,Wei Wang,Hongyu Wu,Travis Nemkov,Andrew W. Subudhi,Sonja Jameson-Van Houten,Colleen G. Julian,Andrew T. Lovering,Kirk C. Hansen,Hong Zhang,Mikhail Bogdanov,William Dowhan,Jianping Jin,Rodney E. Kellems,Holger K. Eltzschig,Michael R. Blackburn,Robert C. Roach,Yang Xia,Yang Xia +32 more
TL;DR: It is reported that in healthy lowlanders, plasma adenosine levels are rapidly induced by initial ascent to high altitude and achieved even higher levels upon re-ascent, a feature that is positively associated with quicker acclimatization.
Elevated Ecto-5'-nucleotidase-Mediated Increased Renal Adenosine Signaling Via A2B Adenosine Receptor Contributes to Chronic Hypertension
Weiru Zhang,Yujin Zhang,Wei Wang,Yingbo Dai,Chen Ning,Renna Luo,Kaiqi Sun,Louise E. Glover,Almut Grenz,Hong Sun,Lijian Tao,Wenzheng Zhang,Sean P. Colgan,Michael R. Blackburn,Holger K. Eltzschig,Rodney E. Kellems,Yang Xia +16 more
TL;DR: In this paper, the expression level of 5′-ectonucleotidase (CD73) was significantly increased in the kidneys of angiotensin II-infused mice, an animal model of hypertensive nephropathy.
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Murine ecto-5'-nucleotidase (CD73): cDNA cloning and tissue distribution
Regina Resta,Scott W. Hooker,Karl R. Hansen,Aletha B. Laurent,J. L. Park,Michael R. Blackburn,Thomas B. Knudsen,Linda F. Thompson +7 more
TL;DR: Culture systems in which murine lymphocytes mature may be useful for examining the mechanisms of NT gene regulation, as well as the function of NT in the immune system.
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Effects of (R)-deoxycoformycin (pentostatin) on intrauterine nucleoside catabolism and embryo viability in the pregnant mouse.
Thomas B. Knudsen,R. S. Winters,S. K. Otey,Michael R. Blackburn,Mark J. Airhart,Joyce K. Church,Richard G. Skalko +6 more
TL;DR: In vivo studies showed a general correlation between embryolethality and the length of adenine nucleoside pool expansion, apparent for exposure on day 7, 8, or 9 but not on day 6, suggesting that the embryo becomes sensitive to adenosine or 2'-deoxyadenosine once the neural plate has formed.
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Adenosine signaling in asthma and chronic obstructive pulmonary disease.
TL;DR: Identifying mediators regulating the chronic nature of asthma and chronic obstructive pulmonary disease is critical towards advancements in treatment options and adenosine has been implicated in promoting the inflammation and airway remodeling seen in chronic lung disease and thus makes an attractive therapeutic target.
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