Michael R. Blackburn
University of Texas Health Science Center at Houston
211 Papers
2.8K Citations
Michael R. Blackburn is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Adenosine & Adenosine deaminase. The author has an hindex of 63, co-authored 205 publications. Previous affiliations of Michael R. Blackburn include University of Texas at Austin & Thomas Jefferson University.
Chat about Author
Papers
Adenosine deaminase deficiency increases thymic apoptosis and causes defective T cell receptor signaling
TL;DR: It is suggested that the metabolic disturbances seen in ADA(-/-) mice affect various signaling pathways that regulate thymocyte survival and function.
Adenosine signaling and the regulation of chronic lung disease
TL;DR: The current progress of research efforts and clinical trials aimed at understanding the complexities of these signaling pathway as they pertain to the development of treatment strategies for chronic lung diseases are discussed.
120
Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice
Almut Grenz,Jessica D. Bauerle,Julee H. Dalton,Douglas Ridyard,Alexander Badulak,Eunyoung Tak,Eóin N. McNamee,Eric T. Clambey,Radu Moldovan,German Reyes,Jost Klawitter,Kelly Ambler,Kristann Magee,Uwe Christians,Kelley S. Brodsky,Katya Ravid,Doo Sup Choi,Jiaming Wen,Dmitriy Lukashev,Michael R. Blackburn,Hartmut Osswald,Imogen R. Coe,Bernd Nürnberg,Volker H. Haase,Yang Xia,Michail V. Sitkovsky,Holger K. Eltzschig +26 more
TL;DR: These studies identify ENT1 and adenosine receptors as key to the process of reestablishing renal perfusion following ischemic AKI, and if translatable from mice to humans, these data have important therapeutic implications.
Adenosine receptors as targets for therapeutic intervention in asthma and chronic obstructive pulmonary disease.
TL;DR: Studies in animal models of airway disease suggest that there may be clinical benefit to the use of A(1), A(3) and A(2B) adenosine receptor antagonists in the treatment of features of asthma and/or COPD, while A( 2A) agonists may also prove effective.
108
Disease-specific gene expression profiling in multiple models of lung disease.
Christina C. Lewis,Jean Yee Hwa Yang,Xiaozhu Huang,Suman K. Banerjee,Michael R. Blackburn,Peter Baluk,Donald M. McDonald,Timothy S. Blackwell,Vijaya Nagabhushanam,Wendy Peters,David Voehringer,David J. Erle +11 more
TL;DR: This multimodel dataset highlights novel genes likely involved in various pathophysiological processes and will be a valuable resource for the investigation of molecular mechanisms underlying lung disease pathogenesis.