Michael R. Blackburn
University of Texas Health Science Center at Houston
211 Papers
2.8K Citations
Michael R. Blackburn is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Adenosine & Adenosine deaminase. The author has an hindex of 63, co-authored 205 publications. Previous affiliations of Michael R. Blackburn include University of Texas at Austin & Thomas Jefferson University.
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Papers
Too much of a good thing: adenosine overload in adenosine-deaminase-deficient mice
TL;DR: Support for this hypothesis comes from studies in adenosine-deaminase-deficient mice where lungAdenosine levels accumulate in association with increased lung inflammation and damage, suggesting that chronic adenosines elevations can affect signaling pathways that mediate aspects of chronic lung disease.
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Alterations in Adenosine Metabolism and Signaling in Patients with Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis
TL;DR: This study provides the first evidence that A2BR signaling can promote the production of inflammatory and fibrotic mediators in patients with these disorders.
A2B adenosine receptors protect against sepsis-induced mortality by dampening excessive inflammation
Balázs Csóka,Zoltán Németh,Zoltán Németh,Peter B. Rosenberger,Holger K. Eltzschig,Zoltán Spolarics,Pal Pacher,Zsolt Selmeczy,Balázs Koscsó,Leonóra Himer,Leonóra Himer,E. Sylvester Vizi,Michael R. Blackburn,Edwin A. Deitch,György Haskó,György Haskó +15 more
TL;DR: It is revealed that the lack of A2B receptors on nonhematopoietic cells that is primarily responsible for the increased inflammation of septic A1B receptor-deficient mice, indicating that A 2B receptor activation may offer a new therapeutic approach for the management of sepsis.
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A3 adenosine receptor signaling contributes to airway inflammation and mucus production in adenosine deaminase-deficient mice.
Hays W. J. Young,Jose G. Molina,Dawn Dimina,Hongyan Zhong,Marlene A. Jacobson,Lee Nien L. Chan,Teh Sheng Chan,James J. Lee,Michael R. Blackburn +8 more
TL;DR: An important role for the A3R is identified in regulating lung eosinophilia and mucus production in an environment of elevated adenosine.
133
Beneficial Role of Erythrocyte Adenosine A2B Receptor–Mediated AMP-Activated Protein Kinase Activation in High-Altitude Hypoxia
Hong Liu,Yujin Zhang,Hongyu Wu,Angelo D'Alessandro,Gennady G. Yegutkin,Anren Song,Kaiqi Sun,Jessica Li,Ning-Yuan Cheng,Aji Huang,Yuan Edward Wen,Ting Ting Weng,Fayong Luo,Travis Nemkov,Hong Sun,Rodney E. Kellems,Harry Karmouty-Quintana,Kirk C. Hansen,Bihong Zhao,Andrew W. Subudhi,Sonja Jameson-Van Houten,Colleen G. Julian,Andrew T. Lovering,Holger K. Eltzschig,Michael R. Blackburn,Robert C. Roach,Yang Xia +26 more
TL;DR: Together, human and mouse studies reveal novel mechanisms of hypoxia adaptation and potential therapeutic approaches for counteracting Hypoxia-induced tissue damage.
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