Michael R. Blackburn
University of Texas Health Science Center at Houston
211 Papers
2.8K Citations
Michael R. Blackburn is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Adenosine & Adenosine deaminase. The author has an hindex of 63, co-authored 205 publications. Previous affiliations of Michael R. Blackburn include University of Texas at Austin & Thomas Jefferson University.
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Papers
Disruption of the adenosine deaminase gene causes hepatocellular impairment and perinatal lethality in mice.
Maki Wakamiya,Michael R. Blackburn,Roland Jurecic,Mark J. McArthur,Robert S. Geske,Joiner Cartwright,Kohnosuke Mitani,Sukeshi Vaishnav,John W. Belmont,Rodney E. Kellems,Milton J. Finegold,Charles A. Montgomery,Allan Bradley,C. Thomas Caskey +13 more
TL;DR: It is demonstrated that ADA is important for the homeostatic maintenance of purines in mice and is the likely cause of liver damage and fetal death during late in utero development.
152
Adenosine-dependent airway inflammation and hyperresponsiveness in partially adenosine deaminase-deficient mice.
Janci L. Chunn,Hays W. J. Young,Suman K. Banerjee,Giuseppe N. Colasurdo,Michael R. Blackburn +4 more
TL;DR: Elevations in adenosine can directly impact lung inflammation and physiology, and this finding may have important implications in the regulation of pulmonary inflammation and airway hyperresponsiveness.
151
Activation of Murine Lung Mast Cells by the Adenosine A3 Receptor
Hongyan Zhong,Sergiy G. Shlykov,Jose G. Molina,Barbara M. Sanborn,Marlene A. Jacobson,Stephen L. Tilley,Michael R. Blackburn +6 more
TL;DR: The results demonstrate that the A3 adenosine receptor plays an important role in adenoine-mediated murine lung mast cell degranulation.
149
Comprehensive characterization of circular RNAs in ~ 1000 human cancer cell lines.
Hang Ruan,Yu Xiang,Junsuk Ko,Shengli Li,Ying Jing,Xiaoyu Zhu,Youqiong Ye,Zhao Zhang,Tingting Mills,Jing Feng,Chun-Jie Liu,Ji Jing,Jin Cao,Bingying Zhou,Li Wang,Yubin Zhou,Chunru Lin,An-Yuan Guo,Xi Chen,Lixia Diao,Wenbo Li,Zhiao Chen,Zhiao Chen,Xianghuo He,Gordon B. Mills,Michael R. Blackburn,Leng Han +26 more
TL;DR: This study provides the characterization of circRNAs in cancer cell lines and explored the potential mechanism of circRNA biogenesis as well as its therapeutic implications and developed a user-friendly data portal to facilitate the related biomedical researches.
Excess adenosine in murine penile erectile tissues contributes to priapism via A2B adenosine receptor signaling
Tiejuan Mi,Shahrzad Abbasi,Hong Zhang,Karen S. Uray,Janci L. Chunn,Ling Wei Xia,Jose G. Molina,Norman W. Weisbrodt,Rodney E. Kellems,Michael R. Blackburn,Yang Xia +10 more
TL;DR: It is shown that excessive adenosine accumulation in the penis contributes to priapism through increased A2BR signaling in both Ada -/- and SCD transgenic mice, and it is suggested that strategies to either reduceAdenosine or block A2 BR activation may prove beneficial in the treatment of this disorder.