Michael R. Blackburn
University of Texas Health Science Center at Houston
211 Papers
2.8K Citations
Michael R. Blackburn is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Adenosine & Adenosine deaminase. The author has an hindex of 63, co-authored 205 publications. Previous affiliations of Michael R. Blackburn include University of Texas at Austin & Thomas Jefferson University.
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Papers
HIF1A up-regulates the ADORA2B receptor on alternatively activated macrophages and contributes to pulmonary fibrosis
Kemly Philip,Tingting Mills,Jonathan Davies,Ning Yuan Chen,Harry Karmouty-Quintana,Fayong Luo,Jose G. Molina,Javier Amione-Guerra,Neeraj Sinha,Ashrith Guha,Holger K. Eltzschig,Michael R. Blackburn +11 more
TL;DR: It is demonstrated that hypoxia‐inducible factor 1‐α (HIF1A) inhibition in late stages of bleomycin‐induced injury attenuates pulmonary fibrosis in association, with reductions in ADORA2B expression in AAMs.
Future directions in idiopathic pulmonary fibrosis research. An NHLBI workshop report.
Timothy S. Blackwell,Andrew M. Tager,Zea Borok,Bethany B. Moore,David A. Schwartz,Kevin J. Anstrom,Ziv Bar-Joseph,Peter B. Bitterman,Michael R. Blackburn,William Bradford,Kevin K. Brown,Harold A. Chapman,Harold R. Collard,Gregory P. Cosgrove,Robin R. Deterding,Ramona Doyle,Kevin R. Flaherty,Christine Kim Garcia,James S. Hagood,Craig A. Henke,Erica L. Herzog,Cory M. Hogaboam,Jeffrey C. Horowitz,Talmadge E. King,James E. Loyd,William Lawson,Clay B. Marsh,Paul W. Noble,Imre Noth,Dean Sheppard,Julie Olsson,Luis A. Ortiz,Thomas G. O'Riordan,Tim D. Oury,Ganesh Raghu,Jesse Roman,Patricia J. Sime,Thomas H. Sisson,Daniel J. Tschumperlin,Shelia M. Violette,Timothy E. Weaver,Rebecca G. Wells,Eric S. White,Naftali Kaminski,Fernando J. Martinez,Thomas A. Wynn,Victor J. Thannickal,Jerry P. Eu +47 more
TL;DR: Recommendations from a workshop aimed at coordinating research efforts and accelerating the development of IPF therapies provide a basis for directing future research and strategic planning by scientific, professional, and patient communities and the NHLBI.
Meconium aspiration produces airway hyperresponsiveness and eosinophilic inflammation in a murine model.
Amir M. Khan,Okan Elidemir,Cynthia E. Epstein,Kevin P. Lally,Hasen Xue,Michael R. Blackburn,Gary L. Larsen,Giuseppe N. Colasurdo +7 more
TL;DR: Meconium aspiration leads to alterations of airway function, lung eosinophilia, goblet cell metaplasia, and cytokine imbalance, thus providing the first evidence of meconium-induced airway dysfunction in a mouse model.
Distinct Roles for the A2B Adenosine Receptor in Acute and Chronic Stages of Bleomycin-Induced Lung Injury
Yang Zhou,Daniel J. Schneider,Eva Morschl,Ling Song,Mesias Pedroza,Harry Karmouty-Quintana,Thuy T. Le,Chun Xiao Sun,Michael R. Blackburn +8 more
TL;DR: In this model, the effects of A2BR removal on acute lung injury were negligible; however, there were substantial reductions in pulmonary fibrosis, supporting a profibrotic role for this receptor.
Gene expression profiling in inflammatory airway disease associated with elevated adenosine.
TL;DR: High-throughput profiling of gene expression by cDNA array hybridization has provided an overview of critical regulatory genes involved in airway inflammation in ADA-deficient mice, and shows that lowering adenosine levels with ADA enzyme therapy has striking effects on gene expression that may be associated with resolution of pulmonary eosinophilia.