Michael R. Blackburn
University of Texas Health Science Center at Houston
211 Papers
2.8K Citations
Michael R. Blackburn is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Adenosine & Adenosine deaminase. The author has an hindex of 63, co-authored 205 publications. Previous affiliations of Michael R. Blackburn include University of Texas at Austin & Thomas Jefferson University.
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Papers
Cadherin-11 contributes to pulmonary fibrosis: potential role in TGF-β production and epithelial to mesenchymal transition
Daniel J. Schneider,Minghua Wu,Thuy T. Le,Seo-Hee Cho,Michael B. Brenner,Michael R. Blackburn,Sandeep K. Agarwal +6 more
TL;DR: Results identify CDH11 as a novel therapeutic target for pulmonary fibrosis as a potential role in TGFβ production and epithelial to mesenchymal transition is identified.
Endogenous adenosine selectively modulates oxidant stress via the A1 receptor in ischemic hearts.
Melissa E. Reichelt,Ana Shanu,Laura Willems,Laura Willems,Paul K. Witting,Paul K. Witting,Natasha A. Ellis,Michael R. Blackburn,John P. Headrick +8 more
TL;DR: Data reveal that local adenosine engages A1 ARs during I/R to limit oxidant damage and enhance outcome selectively, and control of alpha-TOH/alpha-TQ levels may contribute to A1AR-dependent cardioprotection.
Decreased bone resorption in Ezh2 myeloid cell conditional knockout mouse model
Perry C Caviness,Dongzheng Gai,Oxana P. Lazarenko,Michael R. Blackburn,Fenghuang Zhan,Jin-Ran Chen +5 more
TL;DR: In this paper , the polycomb group protein enhancer of zeste homolog 2 (Ezh2), a histone lysine methyltransferase, is associated with epigenetic regulation of numerous cellular processes, but its involvement in bone cell development and homeostasis is not yet clear.
Blockade of equilibrative nucleoside transporter 1/2 protects against Pseudomonas aeruginosa-induced acute lung injury and NLRP3 inflammasome activation.
Eboni Chambers,Alexis White,Alexander Vang,Zhengke Wang,Alfred Ayala,Tingting Weng,Michael R. Blackburn,Gaurav Choudhary,Sharon Rounds,Qing Lu +9 more
TL;DR: The results suggest that targeting ENT1/2 and NLRP3 inflammasome may be novel strategies for prevention and treatment of P. aeruginosa–induced pneumonia and subsequent ARDS.
Adenosine signaling during acute and chronic disease states
TL;DR: Key observations are discussed that define the beneficial and detrimental aspects of adenosine signaling during acute and chronic disease states with an emphasis on cellular processes, such as inflammatory cell regulation, vascular barrier function, and tissue fibrosis.