Michael R. Blackburn
University of Texas Health Science Center at Houston
211 Papers
2.8K Citations
Michael R. Blackburn is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Adenosine & Adenosine deaminase. The author has an hindex of 63, co-authored 205 publications. Previous affiliations of Michael R. Blackburn include University of Texas at Austin & Thomas Jefferson University.
Chat about Author
Papers
Adenosine signaling contributes to ethanol-induced fatty liver in mice (Journal of Clinical Investigation (2009) 119, (582-594) DOI: 10.1172/JCI37409)
Zhongsheng Peng,Pier Andrea Borea,Katia Varani,Tuere Wilder,Herman Yee,Luis Chiriboga,Michael R. Blackburn,G. Azzena,Giuseppe Resta,Bruce N. Cronstein +9 more
TL;DR: Results indicate that adenosine generated by ethanol metabolism plays an important role in ethanol-induced hepatic steatosis via both A1 and A2B receptors and suggest that targeting adenosines receptors may be effective in the prevention of alcohol-induced fatty liver.
The purinergic receptor subtype P2Y2 mediates chemotaxis of neutrophils and fibroblasts in fibrotic lung disease.
Tobias Müller,Susanne Fay,Rodolfo de Paula Vieira,Harry Karmouty-Quintana,Sanja Cicko,Korcan Ayata,Gernot Zissel,Torsten Goldmann,Giuseppe Lungarella,Davide Ferrari,Francesco Di Virgilio,Bernard Robaye,Jean-Marie Boeynaems,Michael R. Blackburn,Marco Idzko +14 more
TL;DR: Mechanical studies demonstrated that recruitment of neutrophils into the lungs, proliferation and migration of lung fibroblasts as well as IL6 production are key P2Y2R mediated processes in the pathogenesis of fibrotic lung diseases in humans and mice.
Interleukin-6 contributes to inflammation and remodeling in a model of adenosine mediated lung injury.
Mesias Pedroza,Daniel J. Schneider,Daniel J. Schneider,Harry Karmouty-Quintana,Julie Coote,Stevan Shaw,Rebecca Corrigan,Rebecca Corrigan,Jose G. Molina,Joseph L. Alcorn,Joseph L. Alcorn,David J. Galas,Richard Gelinas,Michael R. Blackburn,Michael R. Blackburn +14 more
TL;DR: It is demonstrated that adenosine enhances IL-6 signaling pathways to promote aspects of chronic lung disease, suggesting that blocking IL- 6 signaling during chronic stages of disease may provide benefit in halting remodeling processes such as fibrosis and air-space destruction.
Adenosine-dependent pulmonary fibrosis in adenosine deaminase-deficient mice.
TL;DR: It is demonstrated that chronic adenosine elevations are associated with pulmonary fibrosis in ADA-deficient mice and suggested that the adenosines functions as a profibrotic signal in the lung.
Osteopontin in Systemic Sclerosis and Its Role in Dermal Fibrosis
Minghua Wu,Daniel J. Schneider,Maureen D. Mayes,Shervin Assassi,Frank C. Arnett,Filemon K. Tan,Michael R. Blackburn,Sandeep K. Agarwal,Sandeep K. Agarwal +8 more
TL;DR: Plasma OPN levels were increased in SSc patients, including patients with limited and diffuse disease, compared to healthy controls and suggest that OPN may be a novel therapeutic target in S sc patients.