Michael R. Blackburn
University of Texas Health Science Center at Houston
211 Papers
2.8K Citations
Michael R. Blackburn is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Adenosine & Adenosine deaminase. The author has an hindex of 63, co-authored 205 publications. Previous affiliations of Michael R. Blackburn include University of Texas at Austin & Thomas Jefferson University.
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Papers
Deletion of ADORA2B from myeloid cells dampens lung fibrosis and pulmonary hypertension
Harry Karmouty-Quintana,Kemly Philip,Luis F. Acero,Ning Yuan Chen,Tingting Weng,Jose G. Molina,Fayong Luo,Jonathan Davies,Ngoc Bao Le,Isabelle Bunge,Kelly A. Volcik,Thanh-Thuy T. Le,Richard A. Johnston,Yang Xia,Holger K. Eltzschig,Michael R. Blackburn +15 more
TL;DR: Activation of the ADORA2B on macrophages plays an active role in the pathogenesis of lung fibrosis and PH and is associated with reduced expression of CD206 and arginase‐1, markers for AAMs.
The polymeric mucin Muc5ac is required for allergic airway hyperreactivity
Christopher M. Evans,Dorota S Raclawska,Fani Ttofali,Deborah R. Liptzin,Ashley A. Fletcher,Daniel N. Harper,Maggie A. McGing,Melissa M. McElwee,Olatunji W. Williams,Elizabeth Sanchez,Michelle G. Roy,Kristen N. Kindrachuk,Thomas A. Wynn,Holger K. Eltzschig,Michael R. Blackburn,Michael J. Tuvim,William J. Janssen,David A. Schwartz,Burton F. Dickey +18 more
TL;DR: It is shown that Muc5ac is a central effector of allergic inflammation that is required for airway hyperreactivity (AHR) to methacholine (MCh) in mice bred on two well-characterized strain backgrounds and exposed to two separate allergic stimuli, and genetic removal of MUC5ac abolishes AHR.
Extracellular adenosine levels are associated with the progression and exacerbation of pulmonary fibrosis
Fayong Luo,Ngoc Bao Le,Tingting Mills,Ning Yuan Chen,Harry Karmouty-Quintana,Jose G. Molina,Jonathan Davies,Kemly Philip,Kelly A. Volcik,Hong Liu,Yang Xia,Holger K. Eltzschig,Michael R. Blackburn +12 more
TL;DR: Results demonstrate that extracellular adenosine levels are closely associated with the progression of experimental pulmonary fibrosis and that this signaling pathway may mediate fibrosis by regulating IL‐6 and IL‐17 production.
Adenosine and Dopamine Receptors Coregulate Photoreceptor Coupling via Gap Junction Phosphorylation in Mouse Retina
Hongyan Li,Zhijing Zhang,Michael R. Blackburn,Steven W. Wang,Christophe P. Ribelayga,John O'Brien +5 more
TL;DR: It is concluded that adenosine and dopamine coregulate photoreceptor coupling through opposite action on the PKA pathway and Cx36 phosphorylation and that loss of the A2aR hampered D4R gene expression and function.
Extracellular Adenosine Production by ecto-5′-Nucleotidase (CD73) Enhances Radiation-Induced Lung Fibrosis
Florian Wirsdörfer,Simone de Leve,Federica Cappuccini,Therese Eldh,Alina V. Meyer,Eva Gau,Linda F. Thompson,Ning Yuan Chen,Harry Karmouty-Quintana,Ute Fischer,Michael Kasper,Diana Klein,Jerry W. Ritchey,Michael R. Blackburn,Astrid M. Westendorf,Martin Stuschke,Verena Jendrossek +16 more
TL;DR: It is demonstrated that CD73 potentiates radiation-induced lung fibrosis, suggesting that existing pharmacologic strategies for modulating adenosine may be effective in limiting lung toxicities associated with the treatment of thoracic malignancies.