Michael R. Blackburn
University of Texas Health Science Center at Houston
211 Papers
2.8K Citations
Michael R. Blackburn is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Adenosine & Adenosine deaminase. The author has an hindex of 63, co-authored 205 publications. Previous affiliations of Michael R. Blackburn include University of Texas at Austin & Thomas Jefferson University.
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Papers
Crosstalk between the equilibrative nucleoside transporter ENT2 and alveolar Adora2b adenosine receptors dampens acute lung injury
Tobias Eckle,Kelly Hughes,Heidi Ehrentraut,Kelley S. Brodsky,Peter Rosenberger,Doo Sup Choi,Katya Ravid,Tingting Weng,Yang Xia,Michael R. Blackburn,Holger K. Eltzschig +10 more
TL;DR: A newly identified crosstalk pathway between ENT2 and alveolar epithelial Adora2b adenosine receptors dampens acute lung injury and opens possibilities for combined therapies targeted to this protein set.
Altered Hypoxic–Adenosine Axis and Metabolism in Group III Pulmonary Hypertension
Luis J. Garcia-Morales,Ning Yuan Chen,Tingting Weng,Fayong Luo,Jonathan Davies,Kemly Philip,Kelly A. Volcik,Ernestina Melicoff,Javier Amione-Guerra,R.R. Bunge,Brian A. Bruckner,Matthias Loebe,Holger K. Eltzschig,Lavannya M. Pandit,Michael R. Blackburn,Harry Karmouty-Quintana +15 more
TL;DR: The data demonstrate that the hypoxic-adenosine axis is up-regulated in group IIIPH and that subsequent succinate accumulation may play a part in the development of group III PH.
Role of A2B adenosine receptor signaling in adenosine-dependent pulmonary inflammation and injury
Chun Xiao Sun,Hongyan Zhong,Amir Mohsenin,Eva Morschl,Janci L. Chunn,Jose G. Molina,Luiz Belardinelli,Dewan Zeng,Michael R. Blackburn +8 more
TL;DR: Findings suggest that antagonism of A2BAR-mediated responses may prove to be a beneficial therapy in chronic lung diseases associated with increased adenosine, and influences pathways critical for pulmonary inflammation and injury in vivo.
MicroRNA-101 attenuates pulmonary fibrosis by inhibiting fibroblast proliferation and activation
Chaoqun Huang,Xiao Xiao,Ye Yang,Amorite Mishra,Yurong Liang,Xiangming Zeng,Xiaoyun Yang,Dao Xu,Michael R. Blackburn,Craig A. Henke,Lin Liu +10 more
TL;DR: The data suggest that miR-101 is an anti-fibrotic microRNA and a potential therapeutic target for pulmonary fibrosis.
Ecto-5'-nucleotidase (CD73)-mediated adenosine production is tissue protective in a model of bleomycin-induced lung injury.
TL;DR: It is found that adenosine levels are elevated in the lungs of mice injured by the drug bleomycin and increased activity of ecto-5′-nucleotidase (CD73) was found in the lung in conjunction with adenosines elevations, which suggest that CD73-dependent adenoine production contributes to anti-inflammatory pathways in bleomyin-induced lung injury.