Michael R. Blackburn
University of Texas Health Science Center at Houston
211 Papers
2.8K Citations
Michael R. Blackburn is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Adenosine & Adenosine deaminase. The author has an hindex of 63, co-authored 205 publications. Previous affiliations of Michael R. Blackburn include University of Texas at Austin & Thomas Jefferson University.
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Papers
Loss of CD73-mediated extracellular adenosine production exacerbates inflammation and abnormal alveolar development in newborn mice exposed to prolonged hyperoxia.
Huiling Li,Harry Karmouty-Quintana,Ning Yuan Chen,Tingting Mills,Jose G. Molina,Michael R. Blackburn,Jonathan Davies +6 more
TL;DR: It is hypothesized that hyperoxia-induced lung injury leads to CD73-mediated increases in extracellular adenosine, which are detrimental to the newborn lung and causes lung injury associated with an increase inadenosine concentration.
Short-Term Hypoxia Dampens Inflammation in vivo via Enhanced Adenosine Release and Adenosine 2B Receptor Stimulation
Dorien Kiers,Ben Wielockx,Esther Peters,Lucas T. van Eijk,Jelle Gerretsen,Aaron John,Emmy Janssen,Rianne Groeneveld,Mara Peters,Lars Damen,Ana Meneses,Anja Krüger,Jeroen D. Langereis,Aldert Zomer,Michael R. Blackburn,Leo A. B. Joosten,Mihai G. Netea,Niels P. Riksen,Johannes G. van der Hoeven,Gert Jan Scheffer,Holger K. Eltzschig,Peter Pickkers,Matthijs Kox +22 more
TL;DR: It is demonstrated that short-term hypoxia dampens the systemic pro-inflammatory cytokine response through enhanced purinergic signaling in mice and men and may contribute to outcome and provide leads for immunomodulatory treatment strategies for critically ill patients.
Attenuation of Chronic Pulmonary Inflammation in A2B Adenosine Receptor Knockout Mice
Rinat Zaynagetdinov,Sergey Ryzhov,Anna E. Goldstein,Huiyong Yin,Sergey V. Novitskiy,Kasia Goleniewska,Vasiliy V. Polosukhin,Dawn C. Newcomb,Daphne B. Mitchell,Eva Morschl,Yang Zhou,Michael R. Blackburn,R. Stokes Peebles,Italo Biaggioni,Igor Feoktistov +14 more
TL;DR: It is found that repetitive airway allergen challenge induced a significant increase in adenosine levels in fluid recovered by bronchoalveolar lavage, which is in agreement with previous pharmacologic studies suggesting a deleterious role for A(2B) receptor signaling in chronic lung inflammation.
Coordinated Changes in mRNA Turnover, Translation, and RNA Processing Bodies in Bronchial Epithelial Cells following Inflammatory Stimulation†
Yuxin Zhai,Zhenping Zhong,Chyi-Ying A. Chen,Zhenfang Xia,Ling Song,Michael R. Blackburn,Ann-Bin Shyu +6 more
TL;DR: This study reveals an orchestrated change among posttranscriptional mechanisms, which help sustain high levels of inflammatory mediator production in bronchial epithelium during the pathogenesis of inflammatory airway diseases.
CD73-Generated Adenosine Restricts Lymphocyte Migration into Draining Lymph Nodes
Masahide Takedachi,Dongfeng Qu,Yukihiko Ebisuno,Hiroyuki Oohara,Michelle L. Joachims,Stephanie T. McGee,Emiko Maeda,Rodger P. McEver,Toshiyuki Tanaka,Masayuki Miyasaka,Shinya Murakami,Thomas Krahn,Michael R. Blackburn,Linda F. Thompson +13 more
TL;DR: It is shown that increased lymphocyte migration into draining lymph nodes of cd73−/− mice is largely normalized by pretreatment with the selective A2B receptor agonist BAY 60-6583, suggesting that adenosine receptor signaling to restrict lymphocytes migration across HEV may be an important mechanism to control the magnitude of an inflammatory response.