Michael R. Blackburn
University of Texas Health Science Center at Houston
211 Papers
2.8K Citations
Michael R. Blackburn is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Adenosine & Adenosine deaminase. The author has an hindex of 63, co-authored 205 publications. Previous affiliations of Michael R. Blackburn include University of Texas at Austin & Thomas Jefferson University.
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Papers
Coordination of ENT2-dependent adenosine transport and signaling dampens mucosal inflammation
Carol M. Aherne,Colm B. Collins,C. R. Rapp,Kristine E. Olli,Loni Perrenoud,Paul Jedlicka,Jessica L. Bowser,Tingting Mills,Harry Karmouty-Quintana,Michael R. Blackburn,Holger K. Eltzschig +10 more
TL;DR: Increased mucosal A2B signaling following repression or deletion of epithelial Ent2 coordinates the resolution of intestinal inflammation, suggesting the presence of a targetable purinergic network within the intestinal epithelium designed to limit tissue inflammation.
The p97-UFD1L-NPL4 protein complex mediates cytokine-induced IκBα proteolysis.
TL;DR: It is reported that p97, a valosin-containing protein (also called VCP), plays an essential role in the postubiquitinational regulation of IκBα turnover after tumor necrosis factor alpha (TNF-α) or interleukin-1 β (IL-1β) treatment.
Adenosine deaminase enzyme therapy prevents and reverses the heightened cavernosal relaxation in priapism.
Jiaming Wen,Jiaming Wen,Xianzhen Jiang,Yingbo Dai,Yingbo Dai,Yujin Zhang,Yuxin Tang,Hong Sun,Tiejuan Mi,Rodney E. Kellems,Michael R. Blackburn,Yang Xia +11 more
TL;DR: It is found that lowering adenosine levels in penile tissues by PEG-ADA treatment from birth in ADA-deficient mice prevented the increased EFS-induced CCS relaxation associated with priapism.
The importance of adenosine deaminase for lymphocyte development and function.
TL;DR: A mouse model in which levels of ADA can be biochemically and genetically manipulated provides exciting possibilities for uncovering the mechanisms by which this purine catabolic enzyme affects lymphopoiesis.
A1 adenosine receptors mediate hypoxia-induced ventriculomegaly
Christopher P. Turner,Meltem Seli,Laura R. Ment,William B. Stewart,Henglin Yan,Björn Johansson,Bertil B. Fredholm,Michael R. Blackburn,Scott A. Rivkees +8 more
TL;DR: Adenosine acting on A1ARs appears to mediate hypoxia-induced brain injury ventriculomegaly during early postnatal development, supporting a role for adenosine in the pathogenesis of developmental brain injury.