Michael R. Blackburn
University of Texas Health Science Center at Houston
211 Papers
2.8K Citations
Michael R. Blackburn is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Adenosine & Adenosine deaminase. The author has an hindex of 63, co-authored 205 publications. Previous affiliations of Michael R. Blackburn include University of Texas at Austin & Thomas Jefferson University.
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Papers
Equilibrative nucleoside transporter (ENT)-1-dependent elevation of extracellular adenosine protects the liver during ischemia and reperfusion
Michael A. Zimmerman,Eunyoung Tak,Stefan F. Ehrentraut,Maria Kaplan,Antasia Giebler,Tingting Weng,Doo Sup Choi,Michael R. Blackburn,Igal Kam,Holger K. Eltzschig,Almut Grenz +10 more
TL;DR: Findings implicate ENT1 in liver protection from ischemia and reperfusion injury and suggest ENT inhibitors may be of benefit in the prevention or treatment of ischemic liver injury.
In Vivo Transduction by Intravenous Injection of a Lentiviral Vector Expressing Human ADA into Neonatal ADA Gene Knockout Mice: A Novel Form of Enzyme Replacement Therapy for ADA Deficiency
Denise A. Carbonaro,Denise A. Carbonaro,Xiangyang Jin,Denise Petersen,Xingchao Wang,Fred Dorey,Ki Soo Kil,Melissa B. Aldrich,Michael R. Blackburn,Rodney E. Kellems,Donald B. Kohn,Donald B. Kohn +11 more
TL;DR: The long-term expression of enzymatically active ADA achieved by this method, primarily from transduction of liver and lung, restored immunologic function and significantly extended survival.
Adenosine and hyaluronan promote lung fibrosis and pulmonary hypertension in combined pulmonary fibrosis and emphysema.
Scott D. Collum,Jose G. Molina,Ankit Hanmandlu,Weizhen Bi,Mesias Pedroza,Tinne C.J. Mertens,Nancy Wareing,Wang Wei,Cory Wilson,Wenchao Sun,Jayakumar Rajadas,Paul L. Bollyky,Kemly Philip,Dewei Ren,Rajarajan Amirthalingam Thandavarayan,Brian A. Bruckner,Yang Xia,Michael R. Blackburn,Harry Karmouty-Quintana +18 more
TL;DR: Fibrotic deposition and PH are inhibited by the FDA-approved drug hymecromone, suggesting hyaluronan synthesis inhibition as a potential therapy for CPFE and highlighting a novel mechanism through HAS3-positive macrophages.
Increased adenosine contributes to penile fibrosis, a dangerous feature of priapism, via A2B adenosine receptor signaling
Jiaming Wen,Xianzhen Jiang,Yingbo Dai,Yujin Zhang,Yuxin Tang,Hong Sun,Tiejuan Mi,Prasad V. Phatarpekar,Rodney E. Kellems,Michael R. Blackburn,Yang Xia +10 more
TL;DR: It is demonstrated that increasedAdenosine is a novel causative factor contributing to penile fibrosis in two independent animal models of priapism, adenosine deaminase (ADA)‐deficient mice and SCD transgenic mice, and a novel therapeutic possibility for this serious complication is identified.
Neonatal bone marrow transplantation of ADA-deficient SCID mice results in immunologic reconstitution despite low levels of engraftment and an absence of selective donor T lymphoid expansion
Denise A. Carbonaro,Xiangyang Jin,Daniel Cotoi,Tiejuan Mi,Xiao Jin Yu,Dianne C. Skelton,Frederick Dorey,Rodney E. Kellems,Michael R. Blackburn,Donald B. Kohn,Donald B. Kohn +10 more
TL;DR: The absence of selective reconstitution by donor T lymphocytes in the ADA-deficient mice indicates that restoration of immune function occurred by rescue of endogenous ADA- deficient lymphocytes through cross-correction from the engrafted ADA-replete donor cells.