Michael R. Blackburn
University of Texas Health Science Center at Houston
211 Papers
2.8K Citations
Michael R. Blackburn is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Adenosine & Adenosine deaminase. The author has an hindex of 63, co-authored 205 publications. Previous affiliations of Michael R. Blackburn include University of Texas at Austin & Thomas Jefferson University.
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Papers
Adenosine A2B Receptor and Hyaluronan Modulate Pulmonary Hypertension Associated with Chronic Obstructive Pulmonary Disease
Harry Karmouty-Quintana,Tingting Weng,Luis J. Garcia-Morales,Ning Yuan Chen,Mesias Pedroza,Hongyan Zhong,Jose G. Molina,R.R. Bunge,Brian A. Bruckner,Yang Xia,Richard A. Johnston,Matthias Loebe,Dewan Zeng,Harish Seethamraju,Luiz Belardinelli,Michael R. Blackburn +15 more
TL;DR: Using an animal model of airspace enlargement and PH, the blockade of ADORA2B is able to attenuate the development of a PH phenotype that correlates with reduced levels of HA deposition in the vessels and the down-regulation of genes involved in the synthesis of HA.
Erythrocyte purinergic signaling components underlie hypoxia adaptation
Kaiqi Sun,Hong Liu,Anren Song,Jeanne M. Manalo,Angelo D'Alessandro,Kirk C. Hansen,Rodney E. Kellems,Holger K. Eltzschig,Michael R. Blackburn,Robert C. Roach,Yang Xia +10 more
TL;DR: An adenosine-dependent "erythrocyte hypoxic memory" was discovered that provides an explanation for fast acclimation upon re-ascent and offers a myriad of novel therapeutic possibilities to counteract various hypoxic conditions.
Adenosine and osteopontin contribute to the development of chronic obstructive pulmonary disease
TL;DR: It is demonstrated that patients with COPD have increased OPN expression within distal airways in association with clinical airway obstruction, and this results suggest that OPN represents a novel biomarker and therapeutic target for patientswith COPD.
Effect of A2B adenosine receptor gene ablation on proinflammatory adenosine signaling in mast cells.
Sergey Ryzhov,Rinat Zaynagetdinov,Anna E. Goldstein,Sergey V. Novitskiy,Mikhail M. Dikov,Michael R. Blackburn,Italo Biaggioni,Igor Feoktistov +7 more
TL;DR: It is demonstrated that genetic ablation of the A2B receptor protein has two distinct effects on BMMCs, one is the previously reported enhancement of Ag-induced degranulation, which is unrelated to adenosine signaling; the other is the loss of adenosines signaling via this receptor subtype that up-regulates IL-13 and vascular endothelial growth factor secretion.
Adenosine Receptors and Inflammation
TL;DR: The potent effects of adenosine signaling on the regulation of inflammation suggest that targeting specificadenosine receptor activation or inactivation using selective agonists and antagonists could have important therapeutic implications in numerous diseases.