Michael R. Blackburn
University of Texas Health Science Center at Houston
211 Papers
2.8K Citations
Michael R. Blackburn is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Adenosine & Adenosine deaminase. The author has an hindex of 63, co-authored 205 publications. Previous affiliations of Michael R. Blackburn include University of Texas at Austin & Thomas Jefferson University.
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Papers
Transforming growth factor β1 alters the 3'-UTR of mRNA to promote lung fibrosis.
Junsuk Ko,Tingting Mills,Jingjing Huang,Ning Yuan Chen,Tinne C.J. Mertens,Scott D. Collum,Garam Lee,Yu Xiang,Leng Han,Yang Zhou,Chun Geun Lee,Jack A. Elias,S. Jyothula,Keshava Rajagopal,Harry Karmouty-Quintana,Michael R. Blackburn +15 more
TL;DR: It is demonstrated here that NUDT21 is depleted by TGFβ1, and the results identified TGF β1 as an APA regulator through N UDT21 depletion amplifying pulmonary fibrosis.
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Adenosine mediated desensitization of cAMP signaling enhances T-cell responses
Ailian Yang,Ashley D. Mucsi,Melanie D. Desrosiers,Jiang-Fan Chen,Jurgen Schnermann,Michael R. Blackburn,Yan Shi +6 more
TL;DR: The results suggest that adenosine receptor desensitization may be a mechanism for T cells to escape the general suppression during early points of T‐cell activation and may emerge as a potential alternative for vaccine adjuvants.
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Resistin deficiency in mice has no effect on pulmonary responses induced by acute ozone exposure.
Shehla S. Razvi,Jeremy B. Richards,Farhan Malik,Kevin R. Cromar,Roger E. Price,Cynthia S. Bell,Tingting Weng,Constance L. Atkins,Chantal Y. Spencer,Katherine J. Cockerill,Amy L. Alexander,Michael R. Blackburn,Joseph L. Alcorn,Ikram U. Haque,Richard A. Johnston +14 more
TL;DR: It is demonstrated that murine resistin is increased in the lungs of wild-type mice following acute O3 exposure but does not promote O3-induced lung pathology.
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IL-6 Mediates 11βHSD Type 2 to Effect Progression of the Mycobacterial Cord Factor Trehalose 6,6′-Dimycolate-Induced Granulomatous Response
April N. Abbott,Kerry J. Welsh,Shen-An Hwang,Paulina Płoszaj,Tina Choudhury,Sydney Boyd,Michael R. Blackburn,Robert L. Hunter,Jeffrey K. Actor +8 more
TL;DR: A model is proposed linking IL-6 to endocrine-derived factors which allows modification of active corticosterone into inert 11-dehydrocorticosterone at the site of granuloma formation to limit excessive parenchymal damage.
Modulation of ischaemic contracture in mouse hearts: A 'supraphysiological' response to adenosine
Melissa E. Reichelt,Laura Willems,Jason Nigel John Peart,Kevin J. Ashton,G. Paul Matherne,Michael R. Blackburn,John P. Headrick +6 more
TL;DR: In this article, the ability of endogenous versus exogenous adenosine to modify contracture (and postischaemic outcomes) in C57/Bl6 mouse hearts was tested. And the authors concluded that adenosinergic inhibition of contracture is solely A1AR mediated.
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