Michael R. Blackburn
University of Texas Health Science Center at Houston
211 Papers
2.8K Citations
Michael R. Blackburn is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Adenosine & Adenosine deaminase. The author has an hindex of 63, co-authored 205 publications. Previous affiliations of Michael R. Blackburn include University of Texas at Austin & Thomas Jefferson University.
Chat about Author
Papers
Coordinate activation of inflammatory gene networks, alveolar destruction and neonatal death in AKNA deficient mice.
Wenbin Ma,Blanca Ortiz-Quintero,Roberto Rangel,Morgan R. McKeller,Sara Herrera-Rodriguez,Eliseo F. Castillo,Kimberly S. Schluns,Mary A. Hall,Huiyuan Zhang,Woong-Kyung Suh,Hitoshi Okada,Tak W. Mak,Yang Zhou,Michael R. Blackburn,Hector Martinez-Valdez +14 more
TL;DR: It is reported that targeted deletions of mouse AKNA, a hypothetical AT-hook-like transcription factor, sensitize mice to pathogen-induced inflammation and cause sudden neonatal death, and the concept of coordinated pathway-specific gene regulation functions modulating the intensity of inflammatory responses is supported.
Patent
Method of preventing and treating airway remodeling and pulmonary inflammation using a2b adenosine receptor antagonists
Dewan Zeng,Michael R. Blackburn,Luiz Belardinelli +2 more
- 14 Oct 2005
TL;DR: In this paper, a method of preventing airway remodeling using A2B adenosine receptor antagonists was proposed, which finds utility in the treatment and prevention of asthma, COPD, pulmonary fibrosis, emphysema, and other pulmonary diseases.
26
Downregulation of CFIm25 amplifies dermal fibrosis through alternative polyadenylation
Tingting Weng,Jingjing Huang,Jingjing Huang,Eric J. Wagner,Junsuk Ko,Minghua Wu,Nancy Wareing,Yu Xiang,Ning Yuan Chen,Ping Ji,Jose G. Molina,Kelly A. Volcik,Leng Han,Maureen D. Mayes,Michael R. Blackburn,Shervin Assassi +15 more
TL;DR: This study implicates the key regulator of alternative polyadenylation, CFIm25 in dermal fibrosis and in systemic sclerosis (scleroderma) pathogenesis, and downregulation promotes the expression of profibrotic factors, exaggerates bleomycin-induced skin fibrosis, while CFIm 25 restoration attenuates skin Fibrosis.
Alveolar Type II Epithelial Cell Dysfunction in Rat Experimental Hepatopulmonary Syndrome (HPS)
Wenli Yang,Bingqian Hu,Wei Wu,Sachin Batra,Michael R. Blackburn,Joseph L. Alcorn,Michael B. Fallon,Junlan Zhang +7 more
TL;DR: The findings support a novel contributing mechanism in experimental HPS that may be relevant to humans and a potential therapeutic target and administration of TNF-α, the bile acid, chenodeoxycholic acid, and FXR nuclear receptor activation induced apoptosis and impaired SP-B and SP-C production in alveolar epithelial cells in vitro.
High Levels of Adenosine Deaminase on Dendritic Cells Promote Autoreactive T Cell Activation and Diabetes in Nonobese Diabetic Mice
Faranak Ghaemi Oskouie,Afshin Shameli,Ailian Yang,Melanie D. Desrosiers,Ashley D. Mucsi,Michael R. Blackburn,Yang Yang,Pere Santamaria,Yan Shi +8 more
TL;DR: It is reported that ADA is upregulated in NOD dendritic cells, which results in their exuberant and spontaneous activation, which triggers autoimmune T cell activation and suggests a potential target for therapeutic intervention.