Michael R. Blackburn
University of Texas Health Science Center at Houston
211 Papers
2.8K Citations
Michael R. Blackburn is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Adenosine & Adenosine deaminase. The author has an hindex of 63, co-authored 205 publications. Previous affiliations of Michael R. Blackburn include University of Texas at Austin & Thomas Jefferson University.
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Papers
Hypoxia-induced Deoxycytidine Kinase Contributes to Epithelial Proliferation in Pulmonary Fibrosis
Tingting Weng,Jens M. Poth,Harry Karmouty-Quintana,Luis J. Garcia-Morales,Ernestina Melicoff,Fayong Luo,Ning Yuan Chen,Christopher M. Evans,R.R. Bunge,Brian A. Bruckner,Matthias Loebe,Kelly A. Volcik,Holger K. Eltzschig,Michael R. Blackburn +13 more
TL;DR: It is suggested that the induction of DCK after hypoxia plays a role in the progression of pulmonary fibrosis by contributing to alveolar epithelial cell proliferation.
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Genetic removal of the A2A adenosine receptor enhances pulmonary inflammation, mucin production, and angiogenesis in adenosine deaminase-deficient mice
TL;DR: Findings suggest that the A(2A)R plays a protective role in the ADA-deficient model of pulmonary inflammation, and levels of the chemokines monocyte chemoattractant protein-1 and CXCL1 were elevated, whereas levels of cytokines such as TNF-alpha and IL-6 were not.
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Elevated adenosine signaling via adenosine A2B receptor induces normal and sickle erythrocyte sphingosine kinase 1 activity
Kaiqi Sun,Yujin Zhang,Mikhail Bogdanov,Hongyu Wu,Anren Song,Jessica Li,William Dowhan,Modupe Idowu,Harinder S. Juneja,Jose G. Molina,Michael R. Blackburn,Rodney E. Kellems,Yang Xia +12 more
TL;DR: It is reported that adenosine induces SphK1 activity in human and mouse sickle and normal erythrocytes in vitro and it is revealed that protein kinase A-mediated extracellular signal-regulated kinase 1/2 activation functioning downstream of ADORA2B underliesadenosine-induced ery Throcyte SphK 1 activity.
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Ontogeny of adenosine deaminase in the mouse decidua and placenta: immunolocalization and embryo transfer studies.
TL;DR: Maternal expression ofADA in the antimesometrial decidua may play a role during establishment of the embryo in the uterine environment, whereas fetal expression of ADA in the trophoblast might be important to placentation.
Adenosine protected against pulmonary edema through transporter- and receptor A2-mediated endothelial barrier enhancement.
Qing Lu,Elizabeth O. Harrington,Julie Newton,Brian Casserly,Gregory Radin,Rod R. Warburton,Yang Zhou,Michael R. Blackburn,Sharon Rounds +8 more
TL;DR: The data suggest that adenosine deaminase inhibition may be useful in treatment of pulmonary edema in settings of ALI and that bothAdenosine transporters and A(2A) and A (2B) receptors are necessary for exerting maximal effect ofadenosine on barrier enhancement.
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