Michael Punzel
Heidelberg University
11 Papers
330 Citations
Michael Punzel is an academic researcher from Heidelberg University. The author has contributed to research in topics: Stem cell & Haematopoiesis. The author has an hindex of 6, co-authored 11 publications. Previous affiliations of Michael Punzel include Huazhong University of Science and Technology & University of Düsseldorf.
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Papers
Single adult human CD34+/Lin-/CD38- progenitors give rise to natural killer cells, B-lineage cells, dendritic cells, and myeloid cells
TL;DR: New insights are provided into the role of the microenvironment niche, which governs the earliest events in lymphoid development, and direct evidence that NK and B-lineage differentiation derive from a common lymphomyeloid hematopoietic progenitor under the same conditions is provided.
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The symmetry of initial divisions of human hematopoietic progenitors is altered only by the cellular microenvironment.
TL;DR: For the first time, it is demonstrated that asymmetric divisions can be altered upon exposure with a stem cell-supporting microenvironment and direct communication between hematopoietic progenitors with stroma cells is required for maintaining self-renewal potential.
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Primitive human hematopoietic cells give rise to differentially specified daughter cells upon their initial cell division
Bernd Giebel,Bernd Giebel,Bernd Giebel,Tao Zhang,Tao Zhang,Tao Zhang,Julia Beckmann,Julia Beckmann,Julia Beckmann,Jan Spanholtz,Jan Spanholtz,Jan Spanholtz,Peter Wernet,Peter Wernet,Peter Wernet,Anthony D. Ho,Anthony D. Ho,Anthony D. Ho,Michael Punzel,Michael Punzel,Michael Punzel +20 more
TL;DR: In this paper, the developmental capacity of separated offspring of primitive human hematopoietic cells at a single-cell level was analyzed and it was shown that the vast majority of the most primitive, in vitro-detectable human HE cells give rise to daughter cells adopting different cell fates; 1 inheriting the developmental capacities of the mother cell, and 1 becoming more specified.
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Functional analysis of initial cell divisions defines the subsequent fate of individual human CD34(+)CD38(-) cells.
TL;DR: Asymmetric divisional behavior of CD34(+)CD38(-)cells cannot be influenced by culture conditions, and Primitive ML-IC can be distinguished from committed CFC by initial quiescence or asymmetric divisions.
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Divisional History and Pluripotency of Human Hematopoietic Stem Cells
Michael Punzel,Anthony D. Ho +1 more
TL;DR: To maintain self‐renewal and multilineage differentiation capacity, hematopoietic stem cell (HSC) proliferation requires both symmetric and asymmetric cell divisions, and it is demonstrated that although mitotic rate, colony efficiency, and percent of asymmetric divisions all decreased with ontogenic age, the fraction of cells undergoing asymmetry was consistently at 45%.
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