Michael Prater
8 Papers
Michael Prater is an academic researcher. The author has contributed to research in topics: Cancer research & Biology. The author has an hindex of 1, co-authored 4 publications.
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Papers
Mapping the Spatial Proteome of Head and Neck Tumors: Key Immune Mediators and Metabolic Determinants in the Tumor Microenvironment
Niyati Jhaveri,B. Ben Cheikh,Nadezhda Nikulina,Ning Ma,Dmytro Klymyshyn,James DeRosa,Ritu Mihani,A. Pratapa,Yasmin Kassim,Sidharth Bommakanti,Olive Shang,Shannon Berry,Nicholas Ihley,Michael Mclane,Yan He,Yi Zheng,James Monkman,Caroline Cooper,Ken O'Byrne,Bhaskar Anand,Michael Prater,Subham Basu,Brett G.M. Hughes,Arutha Kulasinghe,O. Braubach +24 more
TL;DR: Researchers mapped the spatial proteome of head and neck tumors, identifying six immune neighborhoods and four distinct tumor regions with varying protein signatures, shedding light on the heterogeneity of the tumor microenvironment and its impact on immune therapy responses.
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Single-cell Spatial Metabolic and Immune Phenotyping of Head and Neck Cancer Tissues Identifies Tissue Signatures of Response and Resistance to Immunotherapy
Niyati Jhaveri,Bassem Ben Cheikh,Nadya Nikulina,Ning Ma,Dmytro Klymyshyn,James DeRosa,Ritu Mihani,A. Pratapa,Yasmin Kassim,O. Shang,Yan He,Yi Zheng,James Monkman,Caroline Cooper,Kenneth J. O'Byrne,Bhaskar Anand,Michael Prater,Subham Basu,Brett G.M. Hughes,Arutha Kulasinghe,Oliver Braubach +20 more
TL;DR: In this article , the authors applied an ultra-high plex, single-cell spatial protein analysis in head and neck squamous cell carcinomas (HNSCC) to reveal a high degree of intra-tumoral heterogeneity intrinsic to HNSCC and provided unique insights into the biology of the tumor.
Abstract 6774: The development of a spatial metabolic map of immunotherapy sensitive and resistant cutaneous skin carcinoma
Niyati Jhaveri,Dmytro Klymyshyn,Bassem Ben Cheikh,James Monkman,Dan Winkowski,James Mansfield,Subham Basu,Michael Prater,Gabrielle T. Belz,Oliver Braubach,Arutha Kulasinghe +10 more
TL;DR: Jhaveri et al. as discussed by the authors designed a high-dimensional > 50-plex antibody panel identifying cell lineages, activation states, and immune checkpoints, and deployed a combination of antibodies for a multiplexed metabolic readout, to enhance their in situ profiling beyond well-known TME targets.
Abstract 5648: Single cell spatial phenotyping of bladder tumors with a novel mechanism of NKG2A and HLA-E mediated resistance to BCG immunotherapy
Dmytro Klymyshyn,Niyati Jhaveri,Nadine Nelson,Michael Prater,Zhenqin Wu,Steven Hamel,Matthew D. Galsky,Nina Bhardwaj,John P. Sfakianos,Subham Basu,Oliver Braubach,Amir Horowitz +11 more
TL;DR: Klymyshyn et al. as discussed by the authors applied single cell spatial phenotyping to study major subsets of NK cells in the TME of bladder tumors obtained from patient matched tumor sections before and after BCG therapy.
97 Ultrahigh-plex spatial phenotyping of the glioma tumor landscape in IDH-1WTand IDH-1R132Hpatient tissues
Dmytro Klymyshyn,Niyati Jhaveri,Bassem Ben Cheikh,Michael Prater,Nadine Nelson,Seetha Harihan,David Ashley,Michael Brown,Najiba Mammadova,Simon Gregory +9 more
- 31 Oct 2023
TL;DR: Researchers employed ultrahigh-plex spatial phenotyping to analyze glioma tumor landscapes in IDH-1WT and IDH-1R132H patient tissues, revealing high phenotypic diversity in the tumor immune microenvironment and offering insights into differential expression profiles.