Michael Pfleiderer
Baxter International
15 Papers
224 Citations
Michael Pfleiderer is an academic researcher from Baxter International. The author has contributed to research in topics: Recombinant DNA & Vaccinia. The author has an hindex of 7, co-authored 15 publications.
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Papers
Binding of Murine Leukemia Virus Gag Polyproteins to KIF4, a Microtubule-Based Motor Protein
Wankee Kim,Tang Y,Yasushi Okada,Ted A. Torrey,Sisir K. Chattopadhyay,Michael Pfleiderer,Falko G. Falkner,Friedrich Dorner,Wonja Choi,Nobutaka Hirokawa,Herbert C. Morse +10 more
TL;DR: It is suggested that KIF4, a microtubule-associated motor protein that belongs to the kinesin superfamily, could be involved in Gag polyprotein translocation from the cytoplasm to the cell membrane.
Highly Efficient Induction of Protective Immunity by a Vaccinia Virus Vector Defective in Late Gene Expression
G. W. Holzer,G. Remp,Gerhard Antoine,Michael Pfleiderer,O. M. Enzersberger,W. Emsenhuber,Thomas Hämmerle,Franz Gruber,Carsten Urban,Falko G. Falkner,Friedrich Dorner +10 more
TL;DR: The data indicate that late gene expression of the vaccine vector is not required for successful vaccination; earlyvaccinia virus gene expression induces a potent protective immune response, and the new vaccinia virus-based defective vectors are therefore promising live vaccines for prophylaxis and cancer immunotherapy.
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Recombinant human factor X: high yield expression and the role of furin in proteolytic maturation in vivo and in vitro.
Michele Himmelspach,Michael Pfleiderer,Bernhard Fischer,Barbara Plaimauer,Gerhard Antoine,Falko G. Falkner,Friedrich Dorner,Uwe Schlokat +7 more
TL;DR: expression of recombinant human factor X in Chinese hamster ovary cells lacking the endoprotease Furin revealed that propeptide removal still occurred, whereas single chain precursor to light/heavy chain processing was abolished, suggesting that gamma-carboxylation may be a prerequisite for propeptid removal.
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A novel vaccinia virus expression system allowing construction of recombinants without the need for selection markers, plasmids and bacterial hosts
TL;DR: A modified vaccinia virus genome is developed that allows the direct targeted insertion of DNA fragments downstream of a strong vaccine promoter without any further cloning steps and intermediate plasmid constructs and bacterial hosts are not required.
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Patent
Factor x deletion mutants and analogues thereof
Himmelspach Michele,Michael Pfleiderer,Falkner Falko-Guenter,Eibl Johann,Friedrich Dorner,Schlokat Uwe +5 more
- 27 Feb 1998
TL;DR: In this paper, a deletion of the amino acids Arg180 to Arg234 and a modification in the region of amino acid sequence between Gly173 and Arg179 were discussed. But the authors did not specify the methods for the production of factor XΔ analogues.
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