Michael Patrick
12 Papers
Michael Patrick is an academic researcher. The author has contributed to research in topics: Biology & Medicine. The author has co-authored 4 publications.
Chat about Author
Papers
Abstract 5637: Path to the holy grail of spatial biology: Spatial single-cell whole transcriptomes using 6000-plex spatial molecular imaging on FFPE tissue
Shanshan He,Michael Patrick,Jason Reeves,Patrick Danaher,Julian Preciado,Joseph C. Phan,Erin Piazza,Zachary Reitz,Lidan Wu,Rustem Khafizov,Haiyan Zhai,Michael Rhodes,David Ruff,Joseph M. Beechem +13 more
TL;DR: He et al. as mentioned in this paper used the CosMx spatial molecular imaging (SMI) technology to detect 6,000 targets simultaneously in situ on an FFPE human liver cancer tissue.
3
Abstract 6765: Spatial insights into tumor immune evasion illuminated with 1000-plex RNA profiling with CosMx Spatial Molecular Imager
Claire Williams,Jason Reeves,Patrick Danaher,Shanshan He,Sean Kim,Michael Patrick,Julian Preciado,Mark Gregory,Zachary Reitz,Justin Jenkins,Rachel Liu,Sarah Murphy,Christine Kang,Byron Hartman,Vikram Devgan,Michael Rhodes,Joseph M. Beechem +16 more
TL;DR: Williams et al. as discussed by the authors developed the CosMx™ Spatial Molecular Imager (SMI) for analyzing formalin-fixed paraffin-embedded (FFPE) or fresh-frozen (FF) tissue and capturing the expression of over 1000 RNA targets simultaneously with subcellular resolution.
2
86 Reveal spatial signatures of tumor microenvironment and oncogenic pathways using 6,000-plex single-cell spatial molecular imaging on FFPE tissue
S. He,Michael Patrick,David Kroeppler,Patrick Danaher,Jason Reeves,Mark Gregory,Julian Preciado,Olivia Ho-shing,Haiyan Zhai,Michael Rhodes,Joseph M. Beechem +10 more
- 31 Oct 2023
TL;DR: Researchers used 6,000-plex single-cell spatial molecular imaging on FFPE tissue to reveal spatial signatures of tumor microenvironment and oncogenic pathways, providing a novel tool for cancer and therapeutic research at single-cell subcellular resolution.
1
InSituCor: a toolkit for discovering non-trivial spatial correlations in spatial transcriptomics
Patrick Danaher,Dan McGuire,Michael Patrick,David Kroeppler,Haiyan Zhai,Joachim Schmid,Joseph M. Beechem +6 more
TL;DR: InSituCor is introduced, a toolkit for discovering modules of spatially correlated genes that returns only correlations not explainable by obvious factors like the cell type landscape; this spares precious analyst effort for non-trivial findings.
1
99 Spatial insights into tumor immune evasion illuminated with the CosMx™ spatial molecular imager platform
Jason Reeves,Patrick Danaher,Shanshan He,Sean Kim,Michael Patrick,Julian Preciado,Justin Jenkins,Rachel Liu,Sarah Murphy,Christine Kang,Byron Hartman,Vik Devgan,Youngmi Kim,Michael Rhodes,Joseph M. Beechem +14 more
- 01 Nov 2022
TL;DR: CosMx as discussed by the authors is a spatial molecular imager for analyzing formalin-fixed paraffin-embedded (FFPE) or fresh-frozen (FF) tissue and capturing the expression of over 1000 RNA targets simultaneously with subcellular resolution from a single histopathology slide.