Michael Pantze
Hoffmann-La Roche
8 Papers
8 Citations
Michael Pantze is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Cholestasis & Bile Salt Export Pump. The author has an hindex of 7, co-authored 8 publications. Previous affiliations of Michael Pantze include University of Zurich & University of Bern.
Chat about Author
Papers
The endothelin antagonist bosentan inhibits the canalicular bile salt export pump: a potential mechanism for hepatic adverse reactions.
Karin Fattinger,Karin Fattinger,Karin Fattinger,Christoph Funk,Christoph Funk,Christoph Funk,Michael Pantze,Michael Pantze,Michael Pantze,Cornelia Weber,Cornelia Weber,Cornelia Weber,Jürg Reichen,Jürg Reichen,Jürg Reichen,Bruno Stieger,Bruno Stieger,Bruno Stieger,Peter J. Meier,Peter J. Meier,Peter J. Meier +20 more
TL;DR: In this study, inhibition of the hepatocanalicular bile salt export pump (rodents, Bsep; humans, BSEP ABCB11) could account for bosentan‐induced liver injury.
522
Troglitazone-induced intrahepatic cholestasis by an interference with the hepatobiliary export of bile acids in male and female rats. Correlation with the gender difference in troglitazone sulfate formation and the inhibition of the canalicular bile salt export pump (Bsep) by troglitazone and troglitazone sulfate
Christoph Funk,Michael Pantze,Linda Jehle,Christiane Ponelle,Gerd Scheuermann,Mirjana Lazendic,Rodolfo Gasser +6 more
TL;DR: In this paper, the cholestatic potential of troglitazone and its major metabolite, Troglitaxone sulfate, has been investigated in rats.
171
Pharmacokinetics and metabolism of the dipeptidyl peptidase IV inhibitor carmegliptin in rats, dogs, and monkeys.
Olaf Kuhlmann,Axel Paehler,Idelette Weick,Christoph Funk,Michael Pantze,Manfred Zell,Uwe Timm +6 more
TL;DR: The very high extravascular distribution of carmegliptin in the intestinal tissues, as demonstrated in Wistar rats and Beagle dogs, could play a significant role in its therapeutic effect.
7
Cholestatic Potential of Troglitazone as a Possible Factor Contributing to Troglitazone-Induced Hepatotoxicity: In Vivo and in Vitro Interaction at the Canalicular Bile Salt Export Pump (Bsep) in the Rat
TL;DR: A high accumulation potential was observed for trog litazone sulfate in rat liver tissue, indicating that the hepatobiliary export of this conjugated metabolite might represent a rate-limiting step in the overall elimination process of troglitazone.