Michael Orr
Emory University
50 Papers
55 Citations
Michael Orr is an academic researcher from Emory University. The author has contributed to research in topics: Biology & Chemistry. The author has an hindex of 18, co-authored 30 publications.
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Papers
Low-dose cadmium causes metabolic and genetic dysregulation associated with fatty liver disease in mice
Young-Mi Go,Roy L. Sutliff,Joshua D. Chandler,Rahman Khalidur,Bum-Yong Kang,Frank A. Anania,Michael Orr,Li Hao,Bruce A. Fowler,Dean P. Jones +9 more
TL;DR: Results show that low-dose Cd exposure causes liver function changes consistent with a role in NAFLD and possibly also nonalcoholic steatohepatitis.
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Oxidant-Induced Apoptosis in Human Retinal Pigment Epithelial Cells: Dependence on Extracellular Redox State
Shunai Jiang,Siobhan E. Moriarty-Craige,Michael Orr,Jiyang Cai,Jiyang Cai,Paul Sternberg,Paul Sternberg,Dean P. Jones +7 more
TL;DR: The hRPE cells that are exposed to a more oxidized extracellular redox environment have increased susceptibility to oxidant-induced apoptosis through the intrinsic mitochondrial pathway, which could contribute to an age- related decline in cell populations in the retina and thereby provide a potential mechanism for the degenerative changes that are associated with age-related macular degeneration (ARMD).
Metabolic pathways of lung inflammation revealed by high-resolution metabolomics (HRM) of H1N1 influenza virus infection in mice.
Joshua D. Chandler,Xin Hu,Eun-Ju Ko,Soojin Park,Young-Tae Lee,Michael Orr,Jolyn Fernandes,Karan Uppal,Sang-Moo Kang,Dean P. Jones,Young-Mi Go +10 more
TL;DR: The detailed metabolic interactions with cytokines indicate that targeted metabolic interventions may be useful during life-threatening crises related to severe acute infection and inflammation.
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Integrated Redox Proteomics and Metabolomics of Mitochondria to Identify Mechanisms of Cd Toxicity
TL;DR: The results show that mitochondrial protein redox and metabolites are targets in Cd-induced hepatotoxicity and indicate that redox proteomics and metabolomics can be used in an integrated systems approach to investigate complex disease mechanisms.
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Selective targeting of the cysteine proteome by thioredoxin and glutathione redox systems
Young-Mi Go,James R. Roede,Douglas I. Walker,Douglas I. Walker,Duc M. Duong,Nicholas T. Seyfried,Michael Orr,Yongliang Liang,Kurt D. Pennell,Dean P. Jones +9 more
TL;DR: Data show that the Trx system regulates a broader range of proteins than the GSH system, support distinct function of Trx and GSH in cellular redox control, and show for the first time in mammalian cells selective targeting peptidyl Cys and biological pathways due to deficient function of the TrX system.
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