Michael Oehler
Heidelberg University
2 Papers
Michael Oehler is an academic researcher from Heidelberg University. The author has contributed to research in topics: Promoter & Regulation of gene expression. The author has an hindex of 2, co-authored 2 publications.
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Papers
Frequency Modulation of Transcriptional Bursting Enables Sensitive and Rapid Gene Regulation.
TL;DR: It is shown that quantitating the temporal regulation of key gene states (transcriptionally inactive, active, and refractory) provides a parsimonious framework for analyzing gene regulation and demonstrates the relevance of a kinetic, non-equilibrium framework for understanding transcriptional regulation.
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Transcriptional refractoriness is dependent on core promoter architecture.
TL;DR: The results suggest that refractory promoters carry a physical memory of their recent transcription history and genome-wide analysis of light-induced transcription suggests that refractoriness is rather widespread and a property of promoter architecture.