Michael Mullin
Mount Sinai Hospital, Toronto
8 Papers
Michael Mullin is an academic researcher from Mount Sinai Hospital, Toronto. The author has contributed to research in topics: Microtubule & Multipolar spindles. The author has an hindex of 8, co-authored 8 publications. Previous affiliations of Michael Mullin include Lunenfeld-Tanenbaum Research Institute & Mount Sinai Hospital.
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Papers
Affinity-purification coupled to mass spectrometry: basic principles and strategies.
TL;DR: The basic principles used in affinity‐purification coupled to mass spectrometry are reviewed, with an emphasis on tools (both biochemical and computational), which enable the discovery and reporting of high quality protein–protein interactions.
345
A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development.
Masahiro Morita,Lian Wee Ler,Marc R. Fabian,Nadeem Siddiqui,Michael Mullin,Valerie C. Henderson,Tommy Alain,Bruno D. Fonseca,Galina Karashchuk,Christopher F. Bennett,Tomohiro Kabuta,Shinji Higashi,Ola Larsson,Ivan Topisirovic,Robert J. Smith,Anne-Claude Gingras,Anne-Claude Gingras,Nahum Sonenberg +17 more
TL;DR: A model by which the m4EHP-GIGYF2 complex represses translation of a subset of mRNAs during embryonic development is proposed, as was previously reported for d4E HP.
193
The MMS22L-TONSL complex mediates recovery from replication stress and homologous recombination
Lara O'Donnell,Stephanie Panier,Stephanie Panier,Jan Wildenhain,Johnny M. Tkach,Abdallah Al-Hakim,Marie-Claude Landry,Cristina Escribano-Diaz,Rachel K. Szilard,Jordan T.F. Young,Jordan T.F. Young,Meagan Munro,Marella D. Canny,Nadine K. Kolas,Wei Zhang,Wei Zhang,Shane M. Harding,Jarkko Ylanko,Megan Mendez,Michael Mullin,Thomas Sun,Bianca Habermann,Alessandro Datti,Alessandro Datti,Robert G. Bristow,Anne-Claude Gingras,Anne-Claude Gingras,Mike Tyers,Mike Tyers,Mike Tyers,Grant W. Brown,Daniel Durocher,Daniel Durocher +32 more
TL;DR: Results indicate that MMS22L and TONSL are genome caretakers that stimulate the recombination-dependent repair of stalled or collapsed replication forks.
132
Label-free quantitative proteomics and SAINT analysis enable interactome mapping for the human Ser/Thr protein phosphatase 5.
Danalea V. Skarra,Marilyn Goudreault,Hyungwon Choi,Michael Mullin,Alexey I. Nesvizhskii,Anne-Claude Gingras,Anne-Claude Gingras,Richard E. Honkanen,Richard E. Honkanen +8 more
TL;DR: The results presented demonstrate the usefulness of label‐free quantitative proteomics and statistical tools to discriminate between noise and true interactions, even for proteins normally considered as background contaminants.
CEP192 interacts physically and functionally with the K63-deubiquitinase CYLD to promote mitotic spindle assembly.
Maria Ana Gomez-Ferreria,Mikhail Bashkurov,Michael Mullin,Anne-Claude Gingras,Laurence Pelletier +4 more
TL;DR: Mass spectrometry identifies the microtubule binding K63-deubiquitinase CYLD and shows that co-depletion of CYLD alleviates the bipolar spindle assembly defects observed in CEP 192-depleted cells, exposing an intriguing role for CYLD in spindle formation and raising the tantalizing possibility that CEP192 promotes robust mitotic spindleAssembly by regulating K63 -polyubiquItin-mediated signaling through CYLD.