Michael Meuli
University of Zurich
5 Papers
Michael Meuli is an academic researcher from University of Zurich. The author has contributed to research in topics: Transactivation & Innate immune system. The author has an hindex of 4, co-authored 5 publications.
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Papers
Metal-responsive transcription factor 1 (MTF-1) activity is regulated by a nonconventional nuclear localization signal and a metal-responsive transactivation domain.
TL;DR: It is shown that within the DNA-binding domain, a region spanning zinc fingers 1 to 3 harbors a nonconventional nuclear localization signal that confers metal inducibility in distinct cell types when fused to a heterologous DNA- binding domain.
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Deletion of zmp1 improves Mycobacterium bovis BCG-mediated protection in a guinea pig model of tuberculosis
Peter Sander,Simon Clark,Agnese Petrera,Cristina Vilaplana,Michael Meuli,Petra Selchow,Andrea Zelmer,Deepa Mohanan,Nuria Andreu,Emma Rayner,Michael Dal Molin,Gregory J. Bancroft,Pål Johansen,Pere-Joan Cardona,Ann Williams,Erik C. Böttger +15 more
TL;DR: The protective efficacy of BCG zmp1 deletion mutants in a guinea pig model of tuberculosis infection provided enhanced protection by reducing the bacterial load of tubercle bacilli in the lungs of infected guinea pigs, indicating that the improved protection is independent from the BCG sub-strain.
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Mycobacterium tuberculosis Phosphoribosyltransferase Promotes Bacterial Survival in Macrophages by Inducing Histone Hypermethylation in Autophagy-Related Genes
TL;DR: In this article, a previously unknown mechanism in which Mtb phosphoribosyltransferase (MtbPRT) inhibits autophagy in an mTOR, negative regulator of autophag, independent manner by inducing histone hypermethylation (H3K9me2/3) at the Atg5 and Atg7 promoters by activating p38-MAPK- and EHMT2 methyltransferase-dependent signaling pathways.
Mycobacterium tuberculosis EsxO (Rv2346c) promotes bacillary survival by inducing oxidative stress mediated genomic instability in macrophages
Soumitra Mohanty,Michael Dal Molin,Geetanjali Ganguli,Avinash Padhi,Prajna Jena,Petra Selchow,Srabasti Sengupta,Michael Meuli,Peter Sander,Avinash Sonawane +9 more
TL;DR: Ectopic expression of Mtb Rv2346c (esxO), a member of ESAT-6 family proteins, in non-pathogenic Mycobacterium smegmatis strain (MsmRv23 46c) aids host cell invasion and intracellular bacillary persistence and dampens antibacterial effector functions by inducing oxidative stress mediated genomic instability in infected macrophages.
Rifabutin Is Inactivated by Mycobacterium abscessus Arr.
Daniel Schäfle,Petra Selchow,Barbara Borer,Michael Meuli,Anna Rominski,Bettina Schulthess,Peter Sander +6 more
TL;DR: The findings suggest that the efficacy of RBT might be enhanced by rendering RBT resilient to Arr-dependent modification or by blocking M. abscessus Arr activity.