Michael Mathieson
eBay
9 Papers
74 Citations
Michael Mathieson is an academic researcher from eBay. The author has contributed to research in topics: Active learning (machine learning) & Support vector machine. The author has an hindex of 7, co-authored 8 publications. Previous affiliations of Michael Mathieson include University of California, Santa Cruz.
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Papers
Active Learning with support Vector machines in the drug discovery process
TL;DR: A thorough comparative study of various other selection strategies on data sets provided by DuPont Pharmaceuticals is performed and it is shown that the strategies based on the maximum margin hyperplane clearly outperform the simpler ones.
395
Patent
Search result ranking using machine learning
Parashuram Kulkarni,Abdelhalim Abbas,Michael Mathieson,Jingzhou Hua,Jon Degenhardt,Ramakrishnan Natarajan +5 more
- 04 Aug 2011
TL;DR: In this article, a goal model can be created using machine learning and a plurality of data factors can be inputted into the goal model to create a model output, which can then be presented to a user based on the model output.
41
Support Vector Machines for Active Learning in the Drug Discovery Process
Manfred K. Warmuth,Jun Liao,Gunnar Rätsch,Michael Mathieson,Santosh Putta,Christian Lemmen +5 more
- 01 Jan 2002
TL;DR: This work employed the so-called “active learning paradigm” from Machine Learning for selecting the successive batches of compounds and selected the main selection strategy based on the maximum margin hyperplane – generated by “Support Vector Machines”.
37
Lysyl-tRNA synthetase, a target for urgently needed M. tuberculosis drugs
Simon Green,Susan Davis,Sebastian Damerow,Curtis A. Engelhart,Michael Mathieson,Beatriz Baragaña,David A. Robinson,Jevgenia Tamjar,Alice Dawson,Fábio K. Tamaki,Kirsteen Buchanan,John Post,Karen Dowers,Sharon M. Shepherd,Chimed Jansen,Fabio Zuccotto,Ian H. Gilbert,Ola Epemolu,Jennifer Sian Riley,Laste Stojanovski,Maria Osuna-Cabello,Esther Pérez-Herrán,María J. Rebollo,Laura Guijarro López,Patricia Casado Castro,Isabel Camino,Heather C. Kim,James M. Bean,Navid Nahiyaan,Kyu Y. Rhee,Qinglan Wang,Vee Y. Tan,Helena I. Boshoff,Paul J. Converse,Si-Yang Li,Yong S. Chang,Nader Fotouhi,Anna Upton,Eric L. Nuermberger,Dirk Schnappinger,Kevin D. Read,Lourdes Encinas,Robert H. Bates,Paul G. Wyatt,Laura A. T. Cleghorn +44 more
TL;DR: In this paper , a drug-like series based on a fused dihydropyrrolidino-pyrimidine scaffold was developed against M tuberculosis lysyl-tRNA synthetase (LysRS) and cellular studies support this mechanism of action.