Michael Manfred Herold
BASF Plant Science
54 Papers
145 Citations
Michael Manfred Herold is an academic researcher from BASF Plant Science. The author has contributed to research in topics: Metabolome & Metabolite. The author has an hindex of 13, co-authored 50 publications. Previous affiliations of Michael Manfred Herold include French Institute of Health and Medical Research.
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Papers
Metabolomics: a tool for early detection of toxicological effects and an opportunity for biology based grouping of chemicals-from QSAR to QBAR.
B. van Ravenzwaay,Michael Manfred Herold,H. Kamp,M.D. Kapp,E. Fabian,R. Looser,G. Krennrich,W. Mellert,A. Prokoudine,V. Strauss,T. Walk,J. Wiemer +11 more
TL;DR: A metabolome-database containing approximately 500 data rich chemicals, agrochemicals and drugs based upon 28-day studies in rats, which contributes to animal welfare by means of reduction through refinement (2R), but also has potential as a replacement method by analyzing samples from in vitro studies.
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Nutritional impact on the plasma metabolome of rats.
W. Mellert,M.D. Kapp,V. Strauss,J. Wiemer,H. Kamp,T. Walk,R. Looser,A. Prokoudine,E. Fabian,G. Krennrich,Michael Manfred Herold,B. van Ravenzwaay +11 more
TL;DR: There was a profound difference in the metabolite responses to diet restriction in male and female rats, and the effect of nutritional status should be taken into account when evaluating the metabolic profile of a compound.
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Application of in vivo metabolomics to preclinical/toxicological studies: case study on phenytoin-induced systemic toxicity.
H. Kamp,E. Fabian,Sibylle Groeters,Michael Manfred Herold,G. Krennrich,R. Looser,W. Mattes,W. Mellert,A. Prokoudine,P. Ruiz-Noppinger,V. Strauss,T. Walk,J. Wiemer,B. van Ravenzwaay +13 more
TL;DR: A more comprehensive picture of phenytoin's effects is obtained from the metabolome analysis, demonstrating the added value of metabolome data in preclinical/ toxicological studies.
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The individual and combined metabolite profiles (metabolomics) of dibutylphthalate and di(2-ethylhexyl)phthalate following a 28-day dietary exposure in rats.
B. van Ravenzwaay,G. Coelho-Palermo Cunha,V. Strauss,J. Wiemer,E. Leibold,H. Kamp,T. Walk,W. Mellert,R. Looser,A. Prokoudine,E. Fabian,G. Krennrich,Michael Manfred Herold +12 more
TL;DR: Simultaneous exposure to high dose levels of DEHP and DBP resulted in a profile that was significantly different compared to the individual compounds, and the effect of combined treatment on the metabolites was less than additive.
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Influence of strain and sex on the metabolic profile of rats in repeated dose toxicological studies
V. Strauss,J. Wiemer,E. Leibold,H. Kamp,T. Walk,W. Mellert,R. Looser,A. Prokoudine,E. Fabian,G. Krennrich,Michael Manfred Herold,B. van Ravenzwaay +11 more
TL;DR: In this article, the impact of the strain on the metabolite profile of plasma samples in rats dosed with 2500 ppm 2-methyl-4-chlorophenoxyacetic acid (MCPA acid) or 45 mg/kg bw/day 4-chloro-3-nitroaniline (4C3N) for 4 weeks was evaluated.
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