Michael Kiehntopf
University of Jena
170 Papers
736 Citations
Michael Kiehntopf is an academic researcher from University of Jena. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 37, co-authored 145 publications. Previous affiliations of Michael Kiehntopf include Schiller International University.
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Papers
Intensive insulin therapy and pentastarch resuscitation in severe sepsis.
Frank M. Brunkhorst,Christoph Engel,Frank Bloos,Andreas Meier-Hellmann,Max Ragaller,Norbert Weiler,Onnen Moerer,Matthias Gruendling,Michael Oppert,Stefan Grond,Derk Olthoff,Ulrich Jaschinski,Stefan John,Rolf Rossaint,Tobias Welte,Martin Schaefer,Peter M. Kern,Evelyn Kuhnt,Michael Kiehntopf,Christiane S. Hartog,Charles Natanson,Markus Loeffler,Konrad Reinhart +22 more
TL;DR: The use of intensive insulin therapy placed critically ill patients with sepsis at increased risk for serious adverse events related to hypoglycemia and HES was harmful, and its toxicity increased with accumulating doses.
Antioxidants prevent health-promoting effects of physical exercise in humans.
Michael Ristow,Kim Zarse,Andreas Oberbach,Nora Klöting,Marc Birringer,Michael Kiehntopf,Michael Stumvoll,C. Ronald Kahn,Matthias Blüher +8 more
TL;DR: Consistent with the concept of mitohormesis, exercise-induced oxidative stress ameliorates insulin resistance and causes an adaptive response promoting endogenous antioxidant defense capacity and supplementation with antioxidants may preclude these health-promoting effects of exercise in humans.
Correction: Corrigendum: Monocyte-induced recovery of inflammation-associated hepatocellular dysfunction in a biochip-based human liver model
Marko Gröger,Knut Rennert,Benjamin Giszas,Elisabeth Weiß,Julia Dinger,Harald Funke,Michael Kiehntopf,Frank T. Peters,Amelie Lupp,Michael Bauer,Ralf A. Claus,Otmar Huber,Alexander S. Mosig +12 more
TL;DR: This corrects the article DOI: 10.1038/srep21868 to indicate that the author of the paper is a doctor of medicine rather than a scientist, as previously reported.
Effect of Empirical Treatment With Moxifloxacin and Meropenem vs Meropenem on Sepsis-Related Organ Dysfunction in Patients With Severe Sepsis: A Randomized Trial
Frank M. Brunkhorst,Michael Oppert,Gernot Marx,Frank Bloos,Katrin Ludewig,Christian Putensen,Axel Nierhaus,Ulrich Jaschinski,Andreas Meier-Hellmann,Andreas Weyland,Matthias Gründling,Onnen Moerer,Reimer Riessen,Armin Seibel,Maximilian Ragaller,Markus W. Büchler,Stefan John,Friedhelm Bach,Claudia Spies,Lorenz Reill,Harald Fritz,Michael Kiehntopf,Evelyn Kuhnt,Holger Bogatsch,Christoph Engel,Markus Loeffler,Marin H. Kollef,Konrad Reinhart,Tobias Welte +28 more
TL;DR: In this paper, the authors compared the effect of moxifloxacin and meropenem with the effect on sepsis-related organ dysfunction and concluded that meropenems alone did not result in less organ failure.
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A microfluidically perfused three dimensional human liver model.
Knut Rennert,Sandra Steinborn,Marko Gröger,Birgit Ungerböck,Anne-Marie Jank,Josef Ehgartner,Sandor Nietzsche,Julia Dinger,Michael Kiehntopf,Harald Funke,Frank T. Peters,Amelie Lupp,Claudia Gärtner,Torsten Mayr,Michael Bauer,Otmar Huber,Alexander S. Mosig +16 more
TL;DR: It is concluded that the perfused liver organoid shares relevant morphological and functional characteristics with the human liver and represents a new in vitro research tool to study human hepatocellular physiology at the cellular level under conditions close to the physiological situation.
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