Michael Kemmerer
Johnson & Johnson Pharmaceutical Research and Development
6 Papers
14 Citations
Michael Kemmerer is an academic researcher from Johnson & Johnson Pharmaceutical Research and Development. The author has contributed to research in topics: Gene signature & Epoxide hydrolase. The author has an hindex of 5, co-authored 6 publications.
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Papers
Identification of diaryl ether-based ligands for estrogen-related receptor α as potential antidiabetic agents
Raymond J. Patch,Lily Lee Searle,Alexander Kim,Debyendu De,Xizhen Zhu,Hossein Askari,John O’Neill,Marta C. Abad,Dionisios Rentzeperis,Jianying Liu,Michael Kemmerer,Ling Lin,Jyotsna Kasturi,John G. Geisler,James M Lenhard,Mark R. Player,Micheal Gaul +16 more
TL;DR: The development of diaryl ether based thiazolidenediones, which function as selective ligands against this receptor are described, which provides the first demonstration of functional activities of an ERRα ligand in metabolic animal models.
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Inverse gene expression patterns for macrophage activating hepatotoxicants and peroxisome proliferators in rat liver
Michael K. McMillian,Alex Nie,J. Brandon Parker,Angelique Leone,Michael Kemmerer,Stewart Bryant,Judy Herlich,Lynn Yieh,Anton Bittner,Xuejun Liu,Jackson S. Wan,Mark D. Johnson +11 more
TL;DR: The transcriptional patterns detected using this toxicogenomics approach showed relationships between genes and biological pathways requiring complex analysis to be discerned, and confirmed findings from the literature.
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Drug-induced oxidative stress in rat liver from a toxicogenomics perspective
Michael K. McMillian,Alex Nie,J. Brandon Parker,Angelique Leone,Michael Kemmerer,Stewart Bryant,Judy Herlich,Lynn Yieh,Anton Bittner,Xuejun Liu,Jackson S. Wan,Mark D. Johnson,Peter Lord +12 more
TL;DR: In this paper, the authors used gene signature profiles for each of these three classes of hepatotoxicants to categorize over 100 paradigm (and 50+ in-house proprietary) compounds as to their oxidative stress potential in rat liver.
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Limited Additional Release of Cardiac Troponin I and T in Isoproterenol-Treated Beagle Dogs with Cardiac Injury
Xiao Feng,Peter Taggart,LeRoy Hall,Stewart Bryant,Joseph Sansone,Michael Kemmerer,Judy Herlich,Peter Lord +7 more
TL;DR: The objective was to examine the release of cardiac troponins together with CK by repeat dosing in isoproterenol (ISO)-treated beagle dogs, a routinely used animal model in preclinical studies.
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Diabetogenic Effect of a Series of Tricyclic Delta Opioid Agonists Structurally Related to Cyproheptadine
Ellen E. Codd,Judith Baker,Michael R. Brandt,Stewart Bryant,Chaozhong Cai,John R. Carson,Kristen M. Chevalier,Raymond W. Colburn,Timothy P Coogan,Scott L. Dax,Bart DeCorte,Michael Kemmerer,Edmund K. LeGrand,James M Lenhard,Angelique Leone,Ling Lin,John R. Mabus,Mcdonnell Mark E,Michael K. McMillian,James J. McNally,Dennis J. Stone,Charles Y. Wang,Sui-Po Zhang,Christopher M. Flores +23 more
TL;DR: An assay measuring insulin levels in the rat pancreatic β-cell-derived RINm5F cell line established a reliable, economical, and high-throughput screen for DOR agonists lacking diabetogenic potential, regardless of chemotype or target pharmacology.
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