Michael K. E. Schaefer
University of Mainz
7 Papers
168 Citations
Michael K. E. Schaefer is an academic researcher from University of Mainz. The author has contributed to research in topics: Neuroprotection & Dentate gyrus. The author has an hindex of 5, co-authored 7 publications. Previous affiliations of Michael K. E. Schaefer include French Institute of Health and Medical Research & INMED.
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Papers
Knocking down of the KCC2 in rat hippocampal neurons increases intracellular chloride concentration and compromises neuronal survival
Christophe Pellegrino,Christophe Pellegrino,Olena Gubkina,Olena Gubkina,Michael K. E. Schaefer,Michael K. E. Schaefer,Hélène Becq,Hélène Becq,Anastasia Ludwig,Anastasia Ludwig,Marat Mukhtarov,Marat Mukhtarov,Ilona Chudotvorova,Ilona Chudotvorova,Severine Corby,Severine Corby,Yuriy Salyha,Sergey Salozhin,Sergey Salozhin,Piotr Bregestovski,Piotr Bregestovski,Igor Medina,Igor Medina +22 more
TL;DR: It is shown that experimental silencing of endogenous KCC2 using an RNA interference approach or a dominant negative mutant reduces neuronal resistance to toxic insults and opens new avenues for the development of neuroprotective therapy.
Progressive motor neuronopathy: a critical role of the tubulin chaperone TBCE in axonal tubulin routing from the Golgi apparatus.
Michael K. E. Schaefer,Henning Schmalbruch,Emmanuelle Buhler,C. Lopez,Natalia Martin,Jean-Louis Guénet,Georg Haase +6 more
TL;DR: It is concluded that motor axons critically depend on axonal tubulin routing from the Golgi apparatus, a process that involves TBCE and possibly other tubulin chaperones.
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Dimethyl fumarate treatment after traumatic brain injury prevents depletion of antioxidative brain glutathione and confers neuroprotection.
Tobias Krämer,Theresa Grob,Lutz Menzel,Tobias Hirnet,Eva Verena Griemert,Konstantin Radyushkin,Serge C. Thal,Axel Methner,Michael K. E. Schaefer +8 more
TL;DR: It is demonstrated that post‐traumatic DMF treatment improves neurological outcome and reduces brain tissue loss in a clinically relevant model of TBI and suggest that DMf treatment confers neuroprotection after TBI via preservation of brain GSH levels rather than by modulating neuro inflammation.
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Mutant SOD1 detoxification mechanisms in intact single cells.
Sundar Ganesan,Gundula Rohde,Katrin Eckermann,Kamila Sroka,Michael K. E. Schaefer,Christoph P. Dohm,Pawel Kermer,Georg Haase,Fred S. Wouters,Matthias Bähr,Jochen H. Weishaupt +10 more
TL;DR: The results provide the first cell-by-cell-analysis of SOD1 ubiquitination and chaperone interaction and opens new methodological avenues for cell biological research on ALS.
Bumetanide Prevents Brain Trauma-Induced Depressive-Like Behavior
Emmanuelle Goubert,Marc Altvater,Marie-Noelle Rovira,Ilgam Khalilov,Morgane Mazzarino,Anne Sebastiani,Michael K. E. Schaefer,Claudio Rivera,Claudio Rivera,Christophe Pellegrino +9 more
TL;DR: This work finds a strong suppressive effect of the sodium-potassium-chloride importer (NKCC1) specific antagonist bumetanide on the appearance of depressive-like behavior and demonstrates that this alteration in behavior is associated with an impairment of post-traumatic secondary neurogenesis within the dentate gyrus of the hippocampus.