Michael Jun
University of California, Los Angeles
5 Papers
4 Citations
Michael Jun is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Allosteric regulation & Chemistry. The author has an hindex of 2, co-authored 5 publications.
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Papers
Deuterium-reinforced linoleic acid lowers lipid peroxidation and mitigates cognitive impairment in the Q140 knock in mouse model of Huntington's disease.
Asa Hatami,Chunni Zhu,Aroa Relano-Gines,Chris Jean Elias,Arpine Galstyan,Michael Jun,Ginger L. Milne,Charles R. Cantor,Marie-Françoise Chesselet,Mikhail S. Shchepinov +9 more
TL;DR: D‐PUFA administration represents a promising new strategy to broadly reduce rates of LPO, and may be useful in improving a subset of the core deficits in HD.
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A small molecule ApoE4-targeted therapeutic candidate that normalizes sirtuin 1 levels and improves cognition in an Alzheimer’s disease mouse model
Jesus Campagna,Patricia Spilman,Jagodzinska Barbara,Dongsheng Bai,Asa Hatami,Chunni Zhu,Tina Bilousova,Michael Jun,Chris Jean Elias,Johnny Pham,Gregory M. Cole,Gregory M. Cole,Mary Jo LaDu,Michael E. Jung,Dale E. Bredesen,Varghese John +15 more
TL;DR: The results from the testing of a small molecule first-in-class apolipoprotein E4 (ApoE4)-targeted sirtuin1 (SirT1) enhancer, A03, that increases the levels of the neuroprotective enzyme SirT1 while not affecting levels of neurotoxic sIRTuin 2 in vitro in ApoE4-transfected cells are described.
Pharmacological inhibition of nSMase2 reduces brain exosome release and α-synuclein pathology in a Parkinson's disease model.
Chunni Zhu,Tina Bilousova,Samantha Focht,Michael Jun,Chris Jean Elias,Mikhail Melnik,Sujyoti Chandra,Jesus Campagna,Whitaker Cohn,Asa Hatami,Patricia Spilman,Karen H. Gylys,Varghese John +12 more
TL;DR: In this paper, Cambinol (DDL112) was shown to suppress extracellular vesicle (EV)/exosome production in vitro in a cell model and reduced tau seed propagation.
Evaluation of an Allosteric BACE Inhibitor Peptide to Identify Mimetics that Can Interact with the Loop F Region of the Enzyme and Prevent APP Cleavage
Jesus Campagna,Kanagasabai Vadivel,Jagodzinska Barbara,Michael Jun,Tina Bilousova,Patricia Spilman,Varghese John +6 more
TL;DR: The most potent inhibitor from this series, peptide 65007, has a similar substrate cleavage profile to the Ab and reduces sAPPβ levels in cell models and primary neurons, and is a promising lead for discovery of Loop F-interacting small-molecule mimetics as allosteric inhibitors of BACE.
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