Michael Jaye
GlaxoSmithKline
14 Papers
85 Citations
Michael Jaye is an academic researcher from GlaxoSmithKline. The author has contributed to research in topics: Liver X receptor & Foam cell. The author has an hindex of 12, co-authored 14 publications. Previous affiliations of Michael Jaye include Research Triangle Park.
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Papers
Adipophilin Enhances Lipid Accumulation and Prevents Lipid Efflux From THP-1 Macrophages: Potential Role in Atherogenesis
G. Larigauderie,Christophe Furman,Michael Jaye,C. Lasselin,Corinne Copin,Jean-Charles Fruchart,Graciela Castro,Mustapha Rouis +7 more
TL;DR: In this paper, the function of adipophilin in lipid accumulation and cholesterol efflux in THP-1 macrophages was investigated, and it was shown that stimulation of fat expression by modified low-density lipoprotein (LDL) promotes triglycerides and cholesterol storage.
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Discovery of potent, selective sulfonylfuran urea endothelial lipase inhibitors.
Krista B. Goodman,Michael Jonathan Bury,Mui Cheung,Maria Cichy-Knight,Sarah E. Dowdell,Allison K. Dunn,Dennis Lee,Jeffrey A. Lieby,Michael L. Moore,Daryl A. Scherzer,Deyou Sha,Dominic Suarez,Dennis Murphy,Mark R. Harpel,Eric S. Manas,Dean E. McNulty,Roland S. Annan,Rosalie Matico,Benjamin K. Schwartz,John J. Trill,Thomas D. Sweitzer,Da-Yuan Wang,Paul M. Keller,John A. Krawiec,Michael Jaye +24 more
TL;DR: Sulfonylfuran urea 1 was identified in a high-throughput screening campaign as a potent and non-selective EL inhibitor, and modifications leading to improved LPL selectivity were identified.
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Discovery of Substituted Maleimides as Liver X Receptor Agonists and Determination of a Ligand-Bound Crystal Structure
Michael Jaye,John A. Krawiec,Nino Campobasso,Angela Smallwood,Chunyan Qiu,Quinn Lu,John J. Kerrigan,Maite De Los Frailes Alvaro,Bryan A. Laffitte,Wu Schyong Liu,Joseph P. Marino,Craig R. Meyer,Jason Nichols,Derek J. Parks,Paloma Perez,Lea Sarov-Blat,Sheila Seepersaud,Klaudia Steplewski,Scott K. Thompson,Ping Wang,Michael A. Watson,Christine L. Webb,David Haigh,Justin A. Caravella,Colin H. Macphee,Timothy M. Willson,Jon L. Collins +26 more
TL;DR: Substituted 3-(phenylamino)-1H-pyrrole-2,5-diones were identified from a high throughput screen as inducers of human ATP binding cassette transporter A1 expression and GSK3987 was identified as an LXR ligand.
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Therapeutic modulation of transcription factor activity
TL;DR: Aberrant gene expression is a fundamental cause of many disease-associated pathophysiologies and the pharmacological modulation of transcription factor activity represents an attractive therapeutic approach to such disorders.
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Selective Partial Agonism of Liver X Receptor α Is Related to Differential Corepressor Recruitment
Caroline A. Phelan,Joseph M. Weaver,David J. Steger,Shree Joshi,Jeffrey T. Maslany,Jon L. Collins,William J. Zuercher,Timothy M. Willson,M Walker,Michael Jaye,Mitchell A. Lazar +10 more
TL;DR: It is shown that, at sufficiently high concentration, the NR corepressor (NCoR) influences the activity of the liver X receptor (LXR) even in the presence of a potent full agonist that destabilizes NCoR binding.
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