Michael J. Ting
QIMR Berghofer Medical Research Institute
5 Papers
69 Citations
Michael J. Ting is an academic researcher from QIMR Berghofer Medical Research Institute. The author has contributed to research in topics: Stem cell & Receptor tyrosine kinase. The author has an hindex of 5, co-authored 5 publications. Previous affiliations of Michael J. Ting include University of Queensland.
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Papers
EphA3 Maintains Tumorigenicity and Is a Therapeutic Target in Glioblastoma Multiforme
Bryan W. Day,Brett W. Stringer,Fares Al-Ejeh,Michael J. Ting,John W Wilson,Kathleen S. Ensbey,Paul R. Jamieson,Zara C. Bruce,Yi Chieh Lim,Carolin Offenhäuser,Sara Charmsaz,Leanne Cooper,Jennifer K Ellacott,Angus Harding,Lucie Leveque,Po Inglis,Po Inglis,Suzanne Allan,Suzanne Allan,David G. Walker,Martin Lackmann,Geoffrey W. Osborne,Kum Kum Khanna,Brent A. Reynolds,Jason D. Lickliter,Jason D. Lickliter,Andrew W. Boyd,Andrew W. Boyd +27 more
TL;DR: Results identify EphA3 as a functional, targetable receptor in GBM and appears critically involved in maintaining tumor cells in a less differentiated state by modulating mitogen-activated protein kinase signaling.
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Intracellular trafficking and endocytosis of CXCR4 in fetal mesenchymal stem/stromal cells
Rebecca A. Pelekanos,Michael J. Ting,Varda S. Sardesai,Jennifer Ryan,Yaw Chyn Lim,Jerry Ky Y. Chan,Jerry Ky Y. Chan,Jerry Ky Y. Chan,Nicholas M. Fisk,Nicholas M. Fisk,Nicholas M. Fisk +10 more
TL;DR: It is concluded that constitutive endocytosis is implicated in the regulation of CXCR4 membrane expression, and a novel pharmacological strategy to enhance migration of systemically-transplanted cells is suggested.
Activation of ephrin A proteins influences hematopoietic stem cell adhesion and trafficking patterns
Michael J. Ting,Michael J. Ting,Bryan W. Day,Mark D. Spanevello,Andrew W. Boyd,Andrew W. Boyd +5 more
TL;DR: Treating bone marrow cells with EphA3-Fc resulted in a reduction by 31% in donor stem cells homing to the bone marrow and accumulation of donor cells in recipient spleens and greater recovery of donorstem cells from the peripheral blood.
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Epha4-fc treatment reduces ischemia/reperfusion-induced intestinal injury by inhibiting vascular permeability.
Trent M. Woodruff,Mike C. L. Wu,Michael M. Morgan,Nathan T. Bain,Angela Jeanes,Jeffrey Lipman,Michael J. Ting,Andrew W. Boyd,Stephen M. Taylor,Mark G. Coulthard +9 more
TL;DR: In this paper, the Eph/ephrin interaction induces proinflammatory signaling in vivo by inducing vascular leak and neutrophil infiltration, which results in tissue injury in intestinal I/R.
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The Role of Eph Receptor Tyrosine Kinases and Ephrin Ligands in Hematopoietic Cell Development and Function
Michael J. Ting,Andrew W. Boyd +1 more
TL;DR: The current understanding of the function of Eph-ephrin signaling in human and mouse hematopoiesis is described and the possibility that these molecules may be therapeutic targets is also discussed.