Michael J. Taussig
Babraham Institute
102 Papers
1.7K Citations
Michael J. Taussig is an academic researcher from Babraham Institute. The author has contributed to research in topics: Antibody & Ribosome display. The author has an hindex of 38, co-authored 101 publications. Previous affiliations of Michael J. Taussig include University of Manchester & Scripps Research Institute.
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Papers
Crystal structure of a Staphylococcus aureus protein A domain complexed with the Fab fragment of a human IgM antibody: Structural basis for recognition of B-cell receptors and superantigen activity
Marc Graille,Enrico A. Stura,A.L. Corper,Brian J. Sutton,Michael J. Taussig,Jean-Baptiste Charbonnier,Gregg J. Silverman +6 more
TL;DR: Staphylococcus aureus produces a virulence factor, protein A (SpA), that contains five homologous Ig-binding domains that rely on a sequence-restricted conformational binding with residue side chains, suggesting that this common bacterial pathogen has adopted distinct molecular recognition strategies for affecting large sets of B and T lymphocytes.
604
Antibody-Ribosome-mRNA (ARM) Complexes as Efficient Selection Particles for in vitro Display and Evolution of Antibody Combining Sites
Mingyue He,Michael J. Taussig +1 more
TL;DR: A rapid, eukaryotic, in vitro method for selection and evolution of antibody combining sites using antibody-ribosome-mRNA (ARM) complexes as selection particles, which has the potential to be applied equally for selection of receptors or peptides from libraries.
326
Crystal structure of alkaline phosphatase from human placenta at 1.8 A resolution. Implication for a substrate specificity.
TL;DR: The crystal structure reveals that during evolution, only the overall features of the enzyme have been conserved with respect to Escherichia coli, and the location of the active site at the bottom of a large valley flanked by an interfacial crown-shaped domain and a domain containing an extra metal ion on the other side suggest that the substrate of PLAP could be a specific phosphorylated protein.
274
ProteomeBinders: planning a European resource of affinity reagents for analysis of the human proteome
Michael J. Taussig,Oda Stoevesandt,Carl A.K. Borrebaeck,Andrew Bradbury,Dolores J. Cahill,Christian Cambillau,Antoine de Daruvar,Stefan Dübel,Jutta Eichler,Ronald Frank,Toby J. Gibson,David E. Gloriam,Larry Gold,Friedrich W. Herberg,Henning Hermjakob,Jörg D. Hoheisel,Thomas O. Joos,Olli Kallioniemi,Manfred Koegl,Zoltán Konthur,Bernhard Korn,Elisabeth Kremmer,Sylvia Krobitsch,Ulf Landegren,Silvère M. van der Maarel,John McCafferty,Serge Muyldermans,Per-Åke Nygren,Sandrine Palcy,Andreas Plückthun,Bojan Polić,Michael Przybylski,Petri Saviranta,Alan Sawyer,David James Sherman,Arne Skerra,Markus F. Templin,Marius Ueffing,Mathias Uhlén +38 more
TL;DR: ProteomeBinders is a new European consortium aiming to establish a comprehensive resource of well-characterized affinity reagents, including but not limited to antibodies, for analysis of the human proteome.
Single Step Generation of Protein Arrays From DNA by Cell-Free Expression and in Situ Immobilisation (PISA Method)
Mingyue He,Michael J. Taussig +1 more
TL;DR: It is shown that human single-chain antibody fragments and an enzyme (luciferase) can be functionally arrayed by the PISA method, and this method can overcome problems of insolubility or degradation associated with bacterial expression of recombinant proteins.
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