Racial and ethnic disparities in pediatric mental health.

The Psychiatric Genomics Consortium-Posttraumatic Stress Disorder group (PGC-PTSD) combined genome-wide case–control molecular genetic data across 11 multiethnic studies to quantify PTSD heritability, to examine potential shared genetic risk with schizophrenia, bipolar disorder, and major depressive disorder and to identify risk loci for PTSD. Examining 20 730 individuals, we report a molecular genetics-based heritability estimate (h2SNP) for European-American females of 29% that is similar to h2SNP for schizophrenia and is substantially higher than h2SNP in European-American males (estimate not distinguishable from zero). We found strong evidence of overlapping genetic risk between PTSD and schizophrenia along with more modest evidence of overlap with bipolar and major depressive disorder. No single-nucleotide polymorphisms (SNPs) exceeded genome-wide significance in the transethnic (overall) meta-analysis and we do not replicate previously reported associations. Still, SNP-level summary statistics made available here afford the best-available molecular genetic index of PTSD—for both European- and African-American individuals—and can be used in polygenic risk prediction and genetic correlation studies of diverse phenotypes. Publication of summary statistics for ∼10 000 African Americans contributes to the broader goal of increased ancestral diversity in genomic data resources. In sum, the results demonstrate genetic influences on the development of PTSD, identify shared genetic risk between PTSD and other psychiatric disorders and highlight the importance of multiethnic/racial samples. As has been the case with schizophrenia and other complex genetic disorders, larger sample sizes are needed to identify specific risk loci.

/pdf/largest-gwas-of-ptsd-n-20-070-yields-genetic-overlap-with-4p50yenuqv.pdf

Largest GWAS of PTSD (N=20 070) yields genetic overlap with schizophrenia and sex differences in heritability

Gender differences in factors influencing alcohol use and drinking progression among adolescents

The Genetics of Stress-Related Disorders: PTSD, Depression, and Anxiety Disorders.

https://onlinelibrary.wiley.com/doi/pdf/10.1002/wps.20656

Post-traumatic stress disorder: a state-of-the-art review of evidence and challenges

Background: Major depression (MD) and posttraumatic stress disorder (PTSD) are highly comorbid. The degree to which a common genetic liability explains the etiology of the MD-PTSD association has not been quantified and has important implications for research and prevention. Methods: This paper presents an analysis of data from 6744 members of the Vietnam Era Twin Registry. MD and PTSD were assessed using the Diagnostic Interview Schedule-III-R in 1991–92. Bivariate twin modeling was conducted to determine the genetic and environmental etiology of the MD-PTSD association. Results: The best-fitting model for the MD-PTSD association included a substantial genetic correlation (r=.77; 95% CI, .50–1.00) and a modest individual-specific environmental correlation (r=.34; 95% CI, .19–.48). Common genetic liability explained 62.5%

Research report Common genetic liability to major depression and posttraumatic stress disorder in men

Mental health Wikipedia January 28th, 2019 Mental health is conventionally defined as a hybrid of absence of a mental disorder and presence of well being Focus is increasing on preventing mental disorders Prevention is beginning to appear in mental health strategies including the 2004 WHO report Prevention of Mental Disorders the 2008 EU Pact for Mental Health and the 2011 US National Prevention Strategy

Recognition and Prevention of Major Mental and Substance Use Disorders

Genetic Influences on Forgiving

Genetic Influence on Marital Status

Paradoxical cognitive trajectories in men from earlier to later adulthood.

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