Michael J. Kuhar
Yerkes National Primate Research Center
573 Papers
15.4K Citations
Michael J. Kuhar is an academic researcher from Yerkes National Primate Research Center. The author has contributed to research in topics: Dopamine & Receptor. The author has an hindex of 121, co-authored 573 publications. Previous affiliations of Michael J. Kuhar include National Institute for Medical Research & Salk Institute for Biological Studies.
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Papers
Cocaine receptors on dopamine transporters are related to self-administration of cocaine
TL;DR: It is shown here that the potencies of cocaine-like drugs in self-administration studies correlate with their potencies in inhibiting [3H]mazindol binding to the dopamine transporters in the rat striatum, but not with theirPotencies in binding to a large number of other presynaptic and postsynaptic binding sites.
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The dopamine hypothesis of the reinforcing properties of cocaine
TL;DR: A variety of evidence suggests a 'dopamine hypothesis' for the reinforcing properties of cocaine that proposes that cocaine binds at the dopamine transporter and mainly inhibits neurotransmitter re-uptake; the resulting potentiation of dopaminergic neurotransmission in mesolimbocortical pathways ultimately causes reinforcement.
1K
Autoradiographic localization of opiate receptors in rat brain. I. Spinal cord and lower medulla.
Samir F. Atweh,Michael J. Kuhar +1 more
TL;DR: In these brain regions, opiate receptors are highly associated with areas receiving small, afferent primary fibers, strategically placed to modulate noxious stimuli as well as explain some visceral side effects of opiate administration.
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Leptin Activates Hypothalamic CART Neurons Projecting to the Spinal Cord
Carol F. Elias,Charlotte E. Lee,Joseph Kelly,Carl J. Aschkenasi,Rexford S. Ahima,Pastor R. Couceyro,Michael J. Kuhar,Clifford B. Saper,Joel K. Elmquist +8 more
TL;DR: The finding that leptin activates CART/POMC neurons innervating sympathetic preganglionic neurons in the thoracic spinal cord suggests that this pathway may contribute to the increased thermogenesis and energy expenditure and decreased body weight observed following leptin administration.
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