Michael J. Hammerling
Northwestern University
16 Papers
25 Citations
Michael J. Hammerling is an academic researcher from Northwestern University. The author has contributed to research in topics: Genetic code & Translation (biology). The author has an hindex of 7, co-authored 13 publications. Previous affiliations of Michael J. Hammerling include University of Texas at Austin.
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Papers
Strategies for in vitro engineering of the translation machinery
TL;DR: Methods to engineer each component of the translation machinery are covered, including transfer RNAs, translation factors, and the ribosome, and future directions and enabling technological advances for the field are discussed.
Bacteriophages use an expanded genetic code on evolutionary paths to higher fitness
Michael J. Hammerling,Jared W. Ellefson,Daniel R. Boutz,Edward M. Marcotte,Andrew D. Ellington,Jeffrey E. Barrick +5 more
TL;DR: It is shown that bacteriophages evolved on a host that incorporates 3-iodotyrosine at the amber stop codon acquired neutral and beneficial mutations to this new amino acid in their proteins, demonstrating that an expanded genetic code increases evolvability.
Decaffeination and measurement of caffeine content by addicted escherichia coli with a refactored N-demethylation operon from pseudomonas putida CBB5
Erik M. Quandt,Michael J. Hammerling,Ryan M. Summers,Peter B. Otoupal,Ben Slater,Razan N. Alnahhas,Aurko Dasgupta,James L. Bachman,Mani Subramanian,Jeffrey E. Barrick +9 more
TL;DR: It is shown that the addicted strain can be used as a biosensor to measure the caffeine content of common beverages and could be useful for reclaiming nutrient-rich byproducts of coffee bean processing and for the cost-effective bioproduction of methylxanthine drugs.
The case for decoupling assembly and submission standards to maintain a more flexible registry of biological parts.
Razan N. Alnahhas,Ben Slater,Yunle Huang,Catherine Mortensen,Jordan W. Monk,Yousef Okasheh,Marco D. Howard,Neil Gottel,Michael J. Hammerling,Jeffrey E. Barrick +9 more
TL;DR: It is argued that the emergence of inexpensive DNA synthesis and versatile assembly methods reduces the utility of coupling submission and assembly standards and proposes a submission standard that is compatible with current quality control strategies while nearly eliminating sequence constraints on submitted parts.
Lyophilization of premixed COVID-19 diagnostic RT-qPCR reactions enables stable long-term storage at elevated temperature.
TL;DR: In this paper, the authors test both lab-developed and commercial SARS-CoV-2 diagnostic RT-qPCR mixes for the ability to be stabilized against elevated temperature by lyophilization.
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