Michael J Cumberbatch
Merck & Co.
12 Papers
241 Citations
Michael J Cumberbatch is an academic researcher from Merck & Co.. The author has contributed to research in topics: Agonist & Receptor. The author has an hindex of 11, co-authored 12 publications.
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Papers
The novel NK1 receptor antagonist MK–0869 (L–754,030) and its water soluble phosphoryl prodrug, L–758,298, inhibit acute and delayed cisplatin-induced emesis in ferrets
F.D. Tattersall,W. Rycroft,Michael J Cumberbatch,G Mason,S Tye,David J. Williamson,J. J. Hale,Sander G. Mills,Paul E. Finke,Malcolm MacCoss,Sharon Sadowski,E. Ber,Margaret A. Cascieri,Raymond G. Hill,D. E. Macintyre,Richard Hargreaves +15 more
TL;DR: Data show that MK-0869 and its prodrug, L-758,298, have good activity against cisplatin-induced emesis in ferrets and provided a basis for the clinical testing of these agents for the treatment of emesis associated with cancer chemotherapy.
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Substance P (neurokinin 1) receptor antagonists enhance dorsal raphe neuronal activity.
Rachel K. Conley,Michael J Cumberbatch,G Mason,David J. Williamson,Timothy Harrison,Karen L Locker,Christopher John Swain,Karen A. Maubach,Ruth O'Donnell,Michael Rigby,Louise Hewson,Smith David W,Nadia M.J. Rupniak +12 more
TL;DR: Findings support other evidence for an antidepressant profile of SPAs and suggest that regulation of DRN neuronal activity may contribute to their antidepressant mechanism of action but in a manner that is distinct from monoamine reuptake inhibitors.
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Chronic substance P (NK1) receptor antagonist and conventional antidepressant treatment increases burst firing of monoamine neurones in the locus coeruleus.
Karen A. Maubach,Karine Martin,Gary G. Chicchi,T. Harrison,Alan Wheeldon,Christopher John Swain,Michael J Cumberbatch,Nadia M.J. Rupniak,Guy R. Seabrook +8 more
TL;DR: Chronic, but not acute, treatment with the substance P receptor antagonist L-760735, induced burst firing of neurones in the locus coeruleus, which resembles that of the conventional antidepressant imipramine, but their effects are dissociable.
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Reversal of behavioural and electrophysiological correlates of experimental peripheral neuropathy by the NK1 receptor antagonist GR205171 in rats
Michael J Cumberbatch,Emma J. Carlson,Andrea Wyatt,Susan Boyce,Raymond G. Hill,Nadia M.J. Rupniak +5 more
TL;DR: In adult rats response latencies to innocuous mechanical stimuli were found to be reduced and, in electrophysiological studies, the receptive fields of dorsal horn neurones were enlarged 7-14 days after chronic constriction injury of the sciatic nerve.
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The effects of 5-HT1A, 5-HT1B and 5-HT1D receptor agonists on trigeminal nociceptive neurotransmission in anaesthetized rats.
TL;DR: In anaesthetized rats, the 5-HT1B/1D receptor agonist, zolmitriptan, inhibited the action potential discharge of single trigeminal neurones to noxious electrical stimulation of the middle meningeal artery.
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